A trial of intensity modulated radiation therapy for cervical cancer (INTERTECC)

Cancer type:

Cervical cancer




Phase 2/3

This trial tried to find out more about a radiotherapy technique called intensity modulated radiation therapy (IMRT) alongside chemotherapy.

It was for women whose cancer has not spread to distant parts of the body.

More about this trial

Chemoradiotherapy is one of the usual treatments for cervical cancer. Radiotherapy has improved in recent years and for some cancers it is possible to shape the beam to the exact treatment area. So you might have fewer side effects. This technique is called intensity modulated radiotherapy (IMRT).

In this trial, researchers looked at a way of planning IMRT to see if it caused fewer side effects than the usual external radiotherapy Open a glossary item. This is called image-guided bone marrow-sparing intensity modulated radiation therapy (IG-BMS-IMRT).

The researchers thought that a scan called a PET-CT could help get better pictures of the area to be treated. This means the doctors could limit radiotherapy to the bone marrow Open a glossary item and nearby organs, for example the bladder. This could help to reduce side effects.

One of the side effects the researchers looked at in detail, is a drop in the number of blood cells. Radiotherapy can affect the cells in the bone marrow that produce your blood cells. This is more likely if you are having treatment to the pelvis Open a glossary item, as you do for cervical cancer. Having a low number of blood cells could delay your treatment.

The aims of the trial were to find out:

  • how well IMRT works for cervical cancer
  • if IMRT reduces side effects compared with usual radiotherapy
  • more about how the treatment affects quality of life Open a glossary item

Summary of results

This trial didn't open in the UK. We don't plan to add a summary of the results. 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Alexandra Stewart  

Supported by

UC San Diego
National Cancer Institute (NCI)

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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