
"I am glad that taking part in a trial might help others on their own cancer journey.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at a drug called dasatinib for . The people taking part have cancer that was tested as part of the Stratified Medicine Programme and found to have particular changes to genes called DDR2 and BRAF.
Researchers can look at a sample of cancer that is removed when you have surgery or a and look for particular changes (mutations) to the genes. We know from research that certain gene changes make the cancer more likely to respond to particular drugs.
In this trial, researchers are looking at the drug dasatinib. It is a type of biological therapy that stops signals that cancer cells use to divide and grow. Doctors already use dasatinib to treat . It may also help people who have other cancers with certain gene changes.
The people taking part in this trial have cancer with changes to the DDR2 or BRAF gene. The aims of the trial are to
You may be able to enter this trial if you
You cannot enter this trial if you
This phase 2 trial will recruit about 65 people. Everybody in the trial takes dasatinib tablets once a day. As long as you don’t have bad side effects, you can take dasatinib for as long as it helps you.
You see the trial team and have some tests before you start treatment. The tests include
You may also need to have an ultrasound scan, a chest X-ray and a bone scan.
If there is some tissue left over from your biopsy, the researchers will use this to look for other gene changes and see if these are affected by dasatinib. You will not need to have another biopsy.
During treatment, you see the trial team
You have a CT or MRI scan 4 times in the first 6 months and then every 3 months throughout the rest of your treatment. If your doctor thinks it necessary, you may have a bone scan, an ultrasound or X-ray at these times instead.
When you finish treatment, the trial team will contact you by phone every 3 months to see how you are.
In people with , the most common side effects of dasatinib include
People with other types of cancer may be less likely to have some of these side effects.
You should not eat grapefruit or pomegranates (or drink their juices) while taking dasatinib, as something in these fruits can affect the drug.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr. Fiona Blackhall
Bristol-Myers Squibb
Experimental Cancer Medicine Centre (ECMC)
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”