
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
This trial was comparing CHOP to PMitCEBo with or without G-CSF for people over 60 with aggressive non Hodgkin lymphoma.
Doctors often use chemotherapy to treat non Hodgkin lymphoma (NHL). Older people don’t always cope as well with chemotherapy as younger people.
This trial was comparing 2 different combinations of chemotherapy drugs called CHOP and PMitCEBO. The researchers wanted to find out which combination was best for treating aggressive NHL in people over 60, and which caused fewer side effects. They were also looking into the benefit of having a growth factor called G-CSF. Growth factors are drugs which help the bone marrow to recover more quickly after chemotherapy.
The aims of the trial were to
The trial team found that in the long term, there was no difference in how well the 2 types of chemotherapy worked. They also found that people in this trial did not benefit from having G-CSF.
The trial recruited 784 people who were over 60 years old and had recently been diagnosed with NHL.
The number of people whose NHL responded to treatment was about the same with both types of chemotherapy. Having G-CSF did not affect the response rate.
The side effects of the treatments were different. More people having PMitCEBO had a drop in the number of blood cells. People who had CHOP chemotherapy had more sickness and hair loss.
In those having G-CSF, fewer people had a drop in the number of blood cells, but this did not seem to affect the number of people who had a serious infection. Having G-CSF did not affect the number of people who had to have their chemotherapy dose reduced because of side effects.
The researchers monitored people in this trial for an average of nearly 4 years. The number of people whose NHL hadn’t come back was the same with both types of chemotherapy.
These results show that PMitCEBO worked as well as CHOP for this group of patients. The 2 treatments last different lengths of time, involve different numbers of hospital visits and cause slightly different side effects. So, the researchers suggest either treatment may be appropriate, depending on somebody’s preference or situation.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists () and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor David Cunningham
Haematology Trials Group
NIHR Clinical Research Network: Cancer
Freephone 0808 800 4040
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”