Cancer Research UK logo.
SearchDonate
  • Search

A trial of CAR T-cell treatment and pembrolizumab for diffuse B cell lymphoma (ALEXANDER)

Overview

Cancer types:

Blood cancers, High grade lymphoma, Lymphoma, Non-Hodgkin lymphoma (NHL)

Status:

Results

Phase:

Phase 1/2

Details

This trial looked at changing immune cells to recognise and attack diffuse B cell lymphoma. The people taking part had their own immune cells called changed. This treatment is called CAR T-cell treatment.

The trial was for people with diffuse B cell lymphoma (DBCL) who had not had CAR T-cell treatment before. And their lymphoma had come back after treatment, or treatment had stopped working.

The trial was open for people to join between 2017 and 2021. The team published the results in 2023.

Recruitment start: 1 September 2017

Recruitment end: 3 November 2021

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Kirit Ardeshna

Supported by

Autolus Ltd

Last reviewed: 25 Jun 2024

CRUK internal database number: 15428

The Dangoor Education logo.

Dangoor Education

About Cancer generously supported by Dangoor Education since 2010. Learn more about Dangoor Education

Patient Information Forum. Trusted Information Creator.
Plain English Campaign award.

Help and support

An icon of a hand shake.

Find a Clinical Trial

Search our clinical trials database for all cancer trials and studies recruiting in the UK.

An icon of two speech bubbles, indicating a conversation.

Cancer Chat forum

Meet and chat to other cancer people affected by cancer.

An icon of a landline phone.

Nurse helpline

Questions about cancer? Call freephone 0808 800 40 40 from 9 to 5 - Monday to Friday. Alternatively, you can email us.