There are 2 parts to this phase 1 trial. In both parts everyone has AZD6738 and gemcitabine.
Only part 1 is open. When part 2 opens we will update the summary to include it.
AZD6738 is a tablet. You take AZD6738 every day for 4 days and then 3 days of not taking it.
Your doctor will tell you how many to take and how often.
You have gemcitabine as a drip into a vein. You have it once a week for 3 weeks and then not have it for 2 weeks.
You have your first dose 2 days after starting AZD6738.
You continue to have treatment as long as it is helping and the side effects aren’t too bad.
Part 1
In this part the trial team need up to 55 people to take part.
The first few people will have a low dose of AZD6738 with their gemcitabine. If all goes well the next few will have a higher dose of AZD6738 with their gemcitabine. This goes on until the safest dose of AZD6738 to give with gemcitabine is found. This is a dose escalation study.
You have a treatment diary to take home. You fill it in every time you have a tablet. You must bring this diary with you when you go to the hospital.
Blood and tissue samples
The will ask for your permission to get a small piece of cancer tissue from when you were first diagnosed.
They will take a small piece of your cancer (biopsy) at 3 different times during the trial if it is safe and possible to do.