
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
This trial looked at using a drug called azacitidine for people who have chronic GvHD.
This trial was open for people to join between 2016 and 2019. The team published the results in 2021.
Graft versus host disease (GvHD) is a possible complication of high dose cancer treatment. It happens after a bone marrow or stem cell transplant from another person.
Chronic GvHD (cGvHD) starts more than 100 days after your transplant. It may affect your skin, gut, liver or mouth. Chronic GvHD may be mild or severe, and for some people can go on for several months or even years.
Steroids are a common treatment for chronic GvHD. Some people:
When this trial was done there was no for people in this situation. So doctors wanted to improve treatment. In this trial they looked at using a chemotherapy drug called azacitidine. Some research suggested that it could be a useful treatment.
The main aims of the trial were to find out:
In this small trial, the researchers found that azacitidine could be a promising treatment for chronic GvHD.
Trial design
This was a phase 2 trial. It was in 2 parts. A few people had azacitidine in part 1. In part 2 the trial team planned to look at azacitidine in a larger group.
14 people joined part 1. Everyone was on steroid treatment when they joined the trial but either:
Everyone had up to of azacitidine as long as it was working and the side effects weren’t too bad. 7 people completed all 6 cycles and some had treatment for a bit longer.
Results
The trial team looked at how well treatment worked within 6 months of starting azacitidine. They looked at symptoms to see if they had improved. They found:
The team also looked at how well treatment was working 6 months after starting trial treatment. At this timepoint:
The team also found that:
Quality of life and GvHD symptoms
Everyone filled in a questionnaire before, during and after treatment. It asked about side effects and how people had been feeling. This is called a quality of life study.
Before joining the trial the most common symptoms of GvHD were skin and mouth problems. The trial team asked people to:
Those whose treatment worked said their symptoms improved and so did their quality of life.
Side effects
Most people had side effects. Some of the side effects were mild but others were more severe. The most common of the more severe side effects included:
One person died because of the side effects of treatment.
Conclusion
The team concluded that azacitidine might be a useful treatment for chronic GvHD. The first part of this trial showed that it worked for enough people to be looked at in part 2.
Azacitidine is being looked at in other trials. Researchers think it could be a useful treatment for people with acute myeloid leukaemia or myelodysplasia whose steroid treatment has stopped working. Researchers think azacitidine might work to treat chronic GvHD in this group of people.
Where this information comes from
We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists () and published in a medical journal. The figures we quote above were provided by the trial team who did the research. We have not analysed the data ourselves.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Ram Malladi
Blood Cancer UK
NIHR Clinical Research Network: Cancer
University of Birmingham
Freephone 0808 800 4040
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.