A trial of AMG 337 for advanced solid tumours that have a large number of copies of a gene called MET

You may be able to join this trial if all of the following apply.

• You have a solid tumour that has spread from where it started and there is no standard treatment available, or you don’t want to have the standard treatment
• Your cancer has a large number of copies of the MET gene (this is called MET amplification). To check this, the trial team will test a sample of your cancer that was removed when you had surgery or a biopsy
• You are well enough to carry out all your normal activities, apart from heavy physical work (performance status of 0 or 1)
• You have satisfactory blood test results
• You are at least 18 years old

As well as the above, you must be willing to use 2 forms of reliable contraception if there is any chance you or your partner could become pregnant. Women must continue to do so for 2 weeks after the last dose of AMG 337 and must not breastfeed during this time. Men must carry on using 2 forms of contraception for 12 weeks after the last dose of AMG 337. They must not donate sperm during this time

You cannot join this trial if any of these apply. You

• Have cancer that has spread to your brain or spinal cord (the central nervous system)
• Are able to have surgery or a combination of chemotherapy and radiotherapy (chemoradiation )
• Have had another experimental drug in the last 4 weeks
• Have had major surgery in the last month or haven’t fully recovered from any recent minor surgery
• Have any other cancer treatment (including radiotherapy ) in the 2 weeks before joining the trial
• Haven’t recovered from the side effects of any other cancer treatment
• Have had any other cancer in the last 3 years, unless it was a very early stage and has been successfully treated (the trial team can advise you about this)
• Have an infection that needs treatment with antibiotics in the week before joining the trial (if you have an uncomplicated urine infection you may be able to take part)
• Have certain problems with your digestive system that could affect how you absorb drugs (the trial team can advise you about this)
• Have had a heart attack in the last 6 months or have certain other heart problems (the trial team can advise you about this)
• Have any other medical condition that the trial team think could affect your taking part
• Take other drugs that can affect body substances called CYP enzymes in the 2 weeks before joining the trial (this includes St John’s Wort)
• Have hepatitis C (you may be able to take part if you have hepatitis B, as long as the condition is stable)
• Are HIV positive
• Are pregnant or breastfeeding