A trial looking at treatment for children and young people with acute lymphoblastic leukaemia and lymphoma (UKALL 2011)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Acute leukaemia
Acute lymphoblastic leukaemia (ALL)
Blood cancers
Children's cancers
Non-Hodgkin lymphoma




Phase 3

This trial is looking at treatment for leukaemia and lymphoma. The children and young people taking part have acute lymphoblastic leukaemia (ALL) or a type of non Hodgkin lymphoma (NHL) called lymphoblastic lymphoma (LBL).

This trial is for children from 1 year old and young people up to the age of 24. We use the term 'you' in this summary, but of course if you are a parent, we are referring to your child.

More about this trial

Doctors treat ALL and LBL with chemotherapy. They use a number of drugs in different combinations. As with all treatments, there are side effects and doctors are always looking for ways to reduce them.

The aims of this trial are to see if changing the standard treatment for children and young people with ALL or LBL will reduce side effects and help stop their disease from coming back.

Who can enter

You may be able to enter this trial if you

You cannot enter this trial if you

  • Have B cell ALL
  • Have ALL that is Philadelphia chromosome positive Open a glossary item or BCR-ABL positive – your doctor can confirm this
  • Have already had treatment for your leukaemia or lymphoma – you may join if you had glucocorticoids (dexamethasone or prednisolone) for no more than 3 days immediately before agreeing to take part in this trial

Trial design

This is a phase 3 trial. It will recruit 2,640 children and young adults.

Some parts of the trial are randomised. The people taking part will be put into groups by a computer. Neither you nor your doctor will be able to decide which group you are in.

Treatment is intensive and will last for several months. It is too complicated to go into detail here, but below is an outline of the trial. Your doctor will be able to tell you more about it.

Your doctor will talk to you about the randomisations when they are due to happen.

You have treatment in 5 stages.

UKALL 2011 diagram for trial

In each stage you have a combination of several chemotherapy drugs. You may have them as a tablet or liquid, a drip into a vein or an injection into a muscle.

The 1st stage is called induction. The aim is to get rid of the cancer.

After this stage you have a bone marrow test to see how well you responded to induction treatment. This is called a minimum residual disease test (MRD). Your doctor will use the result of the MRD to decide how intensive the rest of you treatment should be.

The 2nd stage is called consolidation. You have more chemotherapy to destroy any remaining cancer cells. It also stops the cancer from spreading to the brain and spinal cord.

The 3rd stage is called interim maintenance. During this stage you have less intensive treatment. This is to give you a break from the intensive treatment. You have chemotherapy tablets to take at home.

The 4th stage is called delayed intensification. It is a combination of the induction and consolidation stages. Doctors use it to destroy any remaining cancer cells that may still be there but can’t be found in tests.

The 5th stage is called maintenance. It reduces the risk of cancer coming back after treatment is finished.

Hospital visits

Treatment for leukaemia and lymphoma is very intensive. You will be in and out of hospital for several months whether you take part in this trial or not.

You have bone marrow tests and blood tests regularly as part of this trial. You also have a lumbar puncture, heart trace (ECG) Open a glossary item and heart scan (echocardiogram) Open a glossary item.

Side effects

You have many different chemotherapy drugs as part of this trial. The drugs in the trial include

There is information about the side effects of each of these drugs on the links above. But in summary, the most common side effects include

Your doctor will talk to you about the possible side effects before you agree to take part in this trial.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Ajay Vora

Supported by

Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
University of Birmingham

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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