A trial looking at selumetinib for people with Kaposi's sarcoma (SCART)

You may be able to enter this trial if you

• Have been having HIV treatment for 3 months or longer
• Have Kaposi’s sarcoma that can be measured
• Have Kaposi’s sarcoma that is getting worse
• Have satisfactory blood test results
• Are well enough to be  up and about for at least half the day (performance status 0, 1 or 2)
• Are willing to use reliable contraception during treatment and for 4 weeks after if you are a women and 16 weeks if you are a man if there is any chance that you or your partner could become pregnant
• Are at least 18 years old

You cannot enter this trial if you

• Have already had treatment with a drug that is a Ras, Raf or MEK inhibitor (you can check this with your doctor)
• Have an infection that needs treating (apart from HIV)
• Have raised blood pressure and you can’t have blood pressure medicine or it hasn’t helped
• Have problems with your heart
• Have had major surgery in the last 4 weeks
• Have difficulty taking or absorbing tablets, for example because you feel sick or have inflammatory bowel disease
• Have had treatment on a trial in the last 28 days
• Are pregnant or breastfeeding

There is some evidence that in people of Asian origin process and get rid of selumetinib in a different way. This means the amount of selumetinib in their cells may get very high and this may cause serious side effects.

People of Asian ethnicity are not excluded from this study. But your doctor will make a clinical judgment as to whether the potential risk of higher levels of selumetinib outweighs the potential benefit of treatment.