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A trial looking at VEPEMB chemotherapy for patients over 60 years old with Hodgkin lymphoma (SHIELD study)

Overview

Cancer types:

Blood cancers, Cell type, Hodgkin lymphoma, Lymphoma

Status:

Results

Phase:

Phase 2

Details

This trial was to see if a combination of chemotherapy drugs called VEPEMB worked as well as ABVD chemotherapy for Hodgkin lymphoma.

One of the most common treatments for Hodgkin lymphoma is a combination of chemotherapy called ABVD. This is doxorubicin (Adriamycin), bleomycin, vinblastine and dacarbazine. Because the treatment is very intensive, the side effects can be quite bad. Older people often need to have lower doses of drugs, or sometimes aren’t well enough to have this treatment at all.

Doctors hoped a new combination of drugs called VEPEMB would be as good as ABVD but cause fewer side effects. VEPEMB is a combination of the chemotherapy drugs vinblastine, cyclophosphamide, procarbazine, etoposide, mitoxantrone and bleomycin, and the steroid prednisolone. They hoped it would be better than ABVD for people over 60 years old. The aims of this trial were to find out

  • More about the side effects of VEPEMB

  • How good VEPEMB was for people over 60 years old with Hodgkin lymphoma

Recruitment start: 1 September 2004

Recruitment end: 30 August 2009

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Prof Stephen Proctor

Supported by

Cancer Research UK

Experimental Cancer Medicine Centre (ECMC)

Marrow & Stem Cell Transplant 2000

NIHR Clinical Research Network: Cancer

SHIELD Study Group

The Newcastle upon Tyne Hospitals NHS Foundation Trust

Other information

This is Cancer Research UK trial number CRUKE/03/020.

Last reviewed: 9 July 2012

CRUK internal database number: 558

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