“I think it’s really important that people keep signing up to these type of trials to push research forward.”
A trial looking at treatment with or without radical surgery for mesothelioma (MARS)
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This trial was looking at a particular operation or mesothelioma. It involved removing the affected lung, the
Mesothelioma is cancer of the lining of the lungs (pleura). Doctors can treat mesothelioma with chemotherapy, radiotherapy or surgery. But none of these treatments can cure mesothelioma. As all treatments have side effects, it is important that any benefit from treatment is greater than any harmful effects.
The trial was known as MARS, which stands for Mesothelioma And Radical Surgery. It was a pilot study and the aims were to see
- If EPP surgery helped people with mesothelioma
- Whether it would be possible to carry out a larger trial looking at this
Summary of results
The trial recruited 112 people who had been diagnosed with mesothelioma. After joining the trial, everybody taking part had chemotherapy that included a
They were then put into 1 of 2 treatment groups by a computer. This is called randomisation. But some people were not randomised at this point, because their mesothelioma had got worse, they were not well enough to have surgery, or they chose not to have surgery.
Of the 112 people who joined the trial, 50 were randomised.
- For 24 people, the planned treatment was EPP surgery followed by radiotherapy (for various reasons, 8 people did not have surgery as planned)
- 26 people were randomised not to have EPP surgery
The researchers found that on average, people in the group not having EPP lived longer than those in the planned surgery group.
They also found that people in the planned surgery group rated their quality of life lower.
The trial team concluded that EPP surgery does not offer any benefit for people with mesothelioma and that a larger study looking at this would not be feasible.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Professor Julian Peto
Professor Tom Treasure
Cancer Research UK
Guy's and St Thomas' NHS Foundation Trust
June Hancock Mesothelioma Research Fund
National Institute for Health Research Cancer Research Network (NCRN)
This is Cancer Research UK trial number CRUK/04/003.