A trial looking at treatment for children and young people with Wilms' tumour and clear cell sarcoma of the kidney (UKW-R WT 2001 02)

This trial is looking at treatment for children and young people with Wilms’ tumour and clear cell sarcoma of the kidney that has come back after treatment.

This trial is for children and young people up to and including the age of 17. We use the term ‘you’ in this summary, but if you are a parent, we are referring to your child.

Wilms’ tumour and clear cell sarcoma of the kidney (CCSK) are types of kidney cancer that affect younger children and less often older children. They are usually treated with chemotherapy, surgery and radiotherapy. But sometimes these treatments do not work and the cancer continues to grow, or it comes back (recurs). It is then more difficult to treat these children.

At the moment, there is no standard treatment for this and treatments may vary. This trial aims to develop a standard treatment that is more effective.

The trial will also look at the role of high dose chemotherapy and a bone marrow or stem cell transplant. Researchers think that they may benefit some children.

It is not clear which operations are useful and when it is best to have surgery. So the researchers will also collect information about surgical treatment to see which works best.