A trial looking at treatment for children and young people with neuroblastoma that hasn't spread (NB 2000 09)

This trial was looking at chemotherapy and surgery for children over 1 year old who had neuroblastoma.

We use the term ‘you’ in this summary, but of course if you are a parent, we are referring to your child.

Neuroblastoma is a rare type of cancer that develops in nerve cells, most commonly in nerve cells of the adrenal glands. It usually affects babies and young children.

Children with neuroblastoma usually have a combination of treatments including surgery, chemotherapy and radiotherapy.

This trial was for children who had localised cancer that could not be removed with surgery. Localised means that there are no signs that the cancer has spread to other parts of the body.

Some children with neuroblastoma have too many copies of a gene called MYCN. This is known as MYCN amplification and can affect how neuroblastoma responds to treatment. The children taking part in this trial did not have MYCN amplification

The trial treatment plan was chemotherapy followed by surgery. The aim was to find out how well this treatment worked for children over 1 year old with localised neuroblastoma.