A trial looking at treatment for children and young people with Hodgkin lymphoma (EuroNet-PHL-C1)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Blood cancers
Children's cancers
Hodgkin lymphoma




Phase 3

This trial is comparing different ways of treating Hodgkin lymphoma to help lower the risk of long term side effects. This trial is supported by Cancer Research UK.

This trial is for children and young people under 18 years old. We use the term 'you', but of course if you are a parent, we are referring to your child.

Doctors usually treat Hodgkin's lymphoma with chemotherapy and radiotherapy. These treatments often work very well. But all treatments have side effects and some can be long term. The researchers want to look at different ways of treating Hodgkin lymphoma to see if they can further improve treatment and reduce side effects.

Doctors usually treat Hodgkin lymphoma with a combination of chemotherapy drugs. Many people have radiotherapy after chemotherapy. But doctors think that some people may be having radiotherapy (and the side effects) without really needing it.

The aims of this trial are

  • To see if chemotherapy alone is as good as chemotherapy and radiotherapy for some people with Hodgkin lymphoma
  • To look at the long term effects of these drugs on fertility

Who can enter

You can enter this trial if you

  • Have been diagnosed with Hodgkin lymphoma
  • Are under 18 years old
  • Are prepared to use reliable contraception (if you are sexually active) while you are taking part in the trial

You cannot enter this trial if you

  • Have a type of Hodgkin lymphoma called lymphocyte predominant Hodgkin lymphoma
  • Have already had chemotherapy or radiotherapy
  • Have any other type of cancer
  • Have HIV
  • Have any other serious medical condition
  • Are allergic to (or unable to have) any of the drugs in the trial
  • Have taken part in another trial or had any other experimental treatment less than 30 days before starting this trial
  • Are pregnant or breastfeeding

Trial design

Everyone taking part in this trial will be put in one of 3 treatment groups. The group you are in depends on the stage of your cancer. Your doctor will tell you more about this if you are asked to join the trial.

To start with, everybody will have 2 cycles of treatment with a combination of drugs called OEPA. This is vincristine, etoposide, prednisolone and doxorubicin. Each cycle lasts 4 weeks.

You will have some tests, including a PET scan, 2 weeks after you finish the OEPA chemotherapy. This will show how well the chemotherapy has worked, and whether you will need radiotherapy.

The treatment you have next will depend on which group you are in.

If you are in treatment group 1 and your test results show a good response, you won’t need radiotherapy. If the test results show that your lymphoma may still be active, you will have radiotherapy. You will start this as soon as possible (no more than 35 days) after your last cycle of chemotherapy.

If you are in treatment group 2 or 3, you will have more chemotherapy. You may also have radiotherapy depending on your scan results. Your doctor will discuss this individually with you. Group 2 will have 2 more cycles of chemotherapy. And group 3 will have at least 4 more cycles of chemotherapy.

Please note - when the trial started, there were 2 different types of chemotherapy. The trial was randomised and people had 1 of the 2 chemotherapy combinations below.

But early results showed that the combination containing dacarbazine worked as well as the combination containing procarbazine, so this randomisation was stopped in February 2012. Everybody joining the trial after that who was in treatment group 2 or 3 had COPDAC chemotherapy.

If you have radiotherapy, you generally start this between 2 and 3 weeks after you finish chemotherapy.

For all groups, the researchers  ask if they can take a small sample of blood and keep a sample of tissue from when you had your biopsy to diagnose your Hodgkin lymphoma. They would like to use this for research in the future to learn more about the disease. If you do not want to give these samples, you do not have to. You can still take part in the trial.

Hospital visits

You will see the doctors and have some tests before you take part in this trial. The tests include

You may also need to have a

You will have to go to hospital several times during each cycle of chemotherapy and you will have regular blood tests throughout your treatment. You will go to hospital each day (Monday to Friday) for several weeks if you have radiotherapy.

You will see your doctor 6 weeks after you finish treatment, and then

  • Every 6 to 12 weeks for the first two years
  • Every 3 months for the third year
  • Every 6 months for the next 2 years
  • Your doctor will decide how often they will see you after this

Your doctors will ask you if they can carry out a fertility assessment before your treatment and once a year afterwards, which includes blood tests. If you do not want to have this fertility assessment you can still take part in the trial.

Side effects

Common side effects of the drugs in this trial include

We have more information about the side effects of vincristine, etoposide, doxorubicin, prednisolone (a steroid), cyclophosphamide, dacarbazine and radiotherapy for Hodgkin lymphoma.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Hamish Wallace

Supported by

Cancer Research UK
Cancer Research UK Children's Cancer Trials Team
University of Birmingham
European Paediatric Hodgkin's Lymphoma Network
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer

Other information

This is Cancer Research UK trial number CRUK/08/007.

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 176

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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