Blood cancers, Children's cancers, Non-Hodgkin lymphoma (NHL)
Open
Phase 2/3
This trial is looking at different types of new medicines to treat B cell non-Hodgkin lymphoma that has come back after treatment or got worse during treatment.
The drugs currently being tested are odronextamab and loncastuximab tesirine with chemotherapy. Loncastuximab tesirine is also called lonca.
It is open to children and young adults up to and including the age of 25 with B cell non-Hodgkin lymphoma that has come back after treatment or got worse during treatment.
Cancer Research UK supports this trial.
You pronounce odronextamab as oh-dron-ex-ta-mab.
You pronounce loncastuximab tesirine as lon-cas-tuk-si-mab tes-i-reen.
Please note we use the term ‘you’ in this summary, but of course if you are a parent of a child with cancer, we are referring to your child.
Recruitment start: 2 May 2024
Recruitment end: 1 May 2031
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Amos Burke
University of Birmingham
Cancer Research UK
Fight Kids Cancer
Regeneron Pharmaceuticals
ADC Therapeutics
Innovative Therapies for Children with Cancer (ITCC)
The European Inter-Group for Childhood Non-Hodgkin Lymphoma (EINCHL)
Children’s Oncology Group
This is Cancer Research UK trial number CRUK/21/019.
Last reviewed: 27 April 2025
CRUK internal database number: 19867