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A trial looking at treatment for B cell non-Hodgkin lymphoma that has got worse (Glo-BNHL)

Overview

Cancer types:

Blood cancers, Children's cancers, Non-Hodgkin lymphoma (NHL)

Status:

Open

Phase:

Phase 2/3

Details

This trial is looking at different types of new medicines to treat B cell non-Hodgkin lymphoma that has come back after treatment or got worse during treatment.

The drugs currently being tested are odronextamab and loncastuximab tesirine with chemotherapy. Loncastuximab tesirine is also called lonca.

It is open to children and young adults up to and including the age of 25 with B cell non-Hodgkin lymphoma that has come back after treatment or got worse during treatment.

Cancer Research UK supports this trial.

You pronounce odronextamab as oh-dron-ex-ta-mab.

You pronounce loncastuximab tesirine as lon-cas-tuk-si-mab tes-i-reen.

Please note we use the term ‘you’ in this summary, but of course if you are a parent of a child with cancer, we are referring to your child.

Recruitment start: 2 May 2024

Recruitment end: 1 May 2031

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Amos Burke

Supported by

University of Birmingham

Cancer Research UK

Fight Kids Cancer

Regeneron Pharmaceuticals

ADC Therapeutics

Innovative Therapies for Children with Cancer (ITCC)

The European Inter-Group for Childhood Non-Hodgkin Lymphoma (EINCHL)

Children’s Oncology Group

Other information

This is Cancer Research UK trial number CRUK/21/019.

Last reviewed: 27 April 2025

CRUK internal database number: 19867

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