Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A trial looking at radiotherapy and gemcitabine for people with bladder cancer
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Bladder cancer that has grown into the muscle layer is called invasive bladder cancer. Doctors usually treat this with surgery to remove all or part of the bladder (a radical or partial cystectomy), or with radiotherapy. They sometimes give chemotherapy after surgery or radiotherapy.
Doctors think that chemotherapy and radiotherapy together (called chemo radiation) may be useful for treating invasive bladder cancer. But they are not sure yet how well this will work.
In this trial, people had radiotherapy and gemcitabine. The aim of the trial was to see how well this treatment works for invasive bladder cancer.
Summary of results
The trial team found that giving radiotherapy and gemcitabine together worked well to treat people with invasive bladder cancer.
Everyone taking part in the trial had radiotherapy and gemcitabine. The trial recruited 50 people. Everyone completed their radiotherapy, but only 46 people completed their gemcitabine. Side effects to the bowel was the reason the 4 people did not complete the chemotherapy.
Of the 47 people examined after their treatment, 44 (88%) had no sign of the cancer in their bladder. This is called a
The researchers followed the progress of the 50 people in the trial for an average of 3 years. After this time, 36 were still alive and 32 of these still had the use of their bladder. The other 4 had had their bladder removed, 3 because their cancer came back and one because of treatment side effects.
The researchers believe that the results of this trial call for a larger phase 3 trial looking at radiotherapy and gemcitabine to treat invasive bladder cancer.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Dr Richard Cowan
National Institute for Health Research Cancer Research Network (NCRN)
Royal Preston Hospitals NHS Trust
The Christie NHS Foundation Trust
The Leeds Teaching Hospitals NHS Trust