A trial looking at pazopanib with radiotherapy for people with soft tissue sarcoma (PASART 2)

The following bullet points list the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

You may be able to join this trial if all of the following apply. 

• You have been diagnosed with soft tissue sarcoma and your doctor thinks that radiotherapy and then surgery is the best treatment for it 
• You are able to swallow and absorb tablets 
• You have satisfactory blood tests results
• Your heart is working well 
• You are at least 18 years old
• You are well enough to carry out your normal activities, apart from heavy physical work (performance status of 0 or 1)  
• You are willing to use reliable contraception during treatment and for 6 months afterwards if there is any possibility you or your partner could become pregnant

You cannot join this trial if any of these apply. 

Cancer related

• You have soft tissue sarcoma that has come back (recurrent soft tissue sarcoma) 
• You have Ewing’s sarcoma, a primitive neuro ectodermal tumour (PNET ), rhabdomyosarcoma  or osteosarcoma
• You have had radiotherapy or chemotherapy in the past 2 weeks
• You have had a biological therapy or an experimental treatment in the past month 
• You have had another cancer in the past 5 years apart from successfully treated non melanoma skin cancer or an early cancer (carcinoma in situ ) 

Medical conditions 

• You have problems with your digestive system such as inflammatory bowel disease, colitis, a peptic ulcer  or any other condition that makes you at risk of having a hole in your bowel or stomach (perforation)  
• You have had an operation to remove part of your stomach or bowel (resection)
• You have had a fistula , a hole (perforation) or an abscess  in your tummy in the past 28 day
• You have heart problems such as high blood pressure that is not controlled by medication, congestive heart failure that is causing you symptoms, angina that is not controlled or you have had a heart attack in the past 6 months
• You have had an operation to put a stent  in your heart or a coronary artery bypass graft (CABG) in the last 6 months
• You have a build up of fat in your veins (peripheral vascular disease) that is causing you symptoms or you have had a blood clot in a large vein of your lungs in the past 6 months  
• You have a break in a bone (fracture) or a wound that hasn’t healed
• You have had a large operation or injury (trauma) in the past month 
• You have had blood in your urine (haematuria) or you have coughed up blood (haemoptysis) is the past 4 weeks
• You are bleeding or have a high risk of it (bleeding diathesis)
• You have an infection that needs treatment that reaches your whole body (systemic treatment)
• You have taken drugs that affect body substances called CYP enzymes in the past 2 weeks 
• You have another medical condition or mental health problem that the trial team think could affect you taking part 

Other 

• You are sensitive to pazopanib or any other similar drug
• You are not able to have an MRI scan for any reason, for example you have metal implants such as a pacemaker, surgical clips, implants, pins, plates, you have a fear of being in closed spaces (claustrophobia) or you are allergic to the dye (contrast medium ) given during the scan 
• You are not able to have samples of tissue (biopsy ) taken for any reason  
• You are pregnant or breastfeeding