A trial looking at different ways of giving chemotherapy for primary liver cancer (HEP 1)

Cancer type:

Liver cancer




Phase 3

This trial was comparing chemotherapy given through a drip into a vein, with a treatment called chemoembolisation for primary liver cancer. This trial was supported by Cancer Research UK.

Doctors often use chemotherapy to treat primary liver cancer (hepatic cell carcinoma) that can’t be removed with an operation. Doxorubicin (Adriamycin) is the drug doctors often use.

There are 2 main ways to have chemotherapy for liver cancer. One is to have the drug into a vein in the arm. The chemotherapy goes around the body in the bloodstream, including the liver and the liver cancer cells. This is called systemic treatment.

The other is to have the chemotherapy into an artery that goes directly into the liver. You have the chemotherapy and something that blocks the blood vessel. This keeps the chemotherapy in the liver for longer. It also cuts off the food and oxygen supply to the cancer, helping to kill the cancer cells. This is called chemoembolisation.

In this trial some patients had systemic chemotherapy and some had chemoembolisation. The aim of the trial was to find out which worked best. And to find out more about the side effects.

Summary of results

This trial was never finished so there are no results available.  The researchers were unable to recruit enough patients.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor O J Garden

Supported by

Cancer Research UK
National Institute for Health Research Cancer Research Network (NCRN)

Other information

This is Cancer Research UK trial number CRUK/04/005.

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 375

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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