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A trial looking at chemotherapy for Hodgkin lymphoma (LY09)

Overview

Cancer types:

Blood cancers, Cell type, Hodgkin lymphoma, Lymphoma

Status:

Results

Phase:

Phase 3

Details

This trial looked at 3 different combinations of chemotherapy for Hodgkin lymphoma. This trial was supported by Cancer Research UK.

Doctors often treat Hodgkin lymphoma with a combination of chemotherapy called ABVD. This contains the drugs doxorubicin (Adriamycin), bleomycin, vinblastine and dacarbazine.

When this trial was done, doctors thought that giving more drugs may be helpful. So the people in this trial either had standard ABVD treatment, or one of two newer combinations of chemotherapy. One was a combination of 7 drugs called ChlVPP/EVA (the ‘hybrid’ regime). The other was a combination of 8 drugs calledChlVPP/PABIOE (the ‘alternating’ regime). Doctors called these ‘multi drug regimes’ or MDRs.

The aim of this trial was to find out if either of the MDRs are better than ABVD for Hodgkin lymphoma.

Recruitment start: 1 February 1998

Recruitment end: 30 September 2001

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Prof Peter Johnson

Supported by

Cancer Research UK

Medical Research Council (MRC)

National Institute for Health Research Cancer Research Network (NCRN)

Other information

This is Cancer Research UK trial number CRUK/95/017.

Last reviewed: 12 January 2016

CRUK internal database number: 956

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