
"I am glad that taking part in a trial might help others on their own cancer journey.”
This trial looked at gemcitabine and docetaxel (Taxotere) for women whose cervical cancer had come back after treatment.
Doctors usually treat cervical cancer with surgery and radiotherapy, and sometimes chemotherapy. But sometimes these treatments don’t work very well and the cancer starts to grow again (recurs).
Most women who have chemotherapy for cervical cancer have cisplatin. If the cancer starts to grow again, you can have a second course of cisplatin. But the second course often doesn’t work as well as the first.
Doctors thought the combination of gemcitabine and docetaxel might help women in this situation. But they were not sure how well it would work.
The aim of this trial was to see how well gemcitabine and docetaxel worked for cervical cancer that had come back after cisplatin chemotherapy. And to find out more about the side effects of this combination.
The trial team found that gemcitabine and docetaxel had similar results as other chemotherapy treatments for women whose cervical cancer had come back.
This trial recruited 50 women. The researchers split these women into 2 groups.
In group 1, there were 21 women. Their cancer had come back in the area between their hip bones () only.
In group 2, there were 29 women. Their cancer had come back in other parts of the body, outside of their pelvis.
Everyone had docetaxel and gemcitabine.
Of the women in group 1
Of the women in group 2
The most common side effect was a drop in blood cells causing an increase risk of infection.
The researchers found a drop in the women’s which they say couldn’t have happened by chance, that is to say it was
.
The researchers concluded that the combination of docetaxel and gemcitabine had similar results to other chemotherapy treatments for women whose cervical cancer had come back. They suggest that future trials should look at combining chemotherapy with a biological therapy.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists () and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Paul Symonds
Eli Lilly and Company Limited
Experimental Cancer Medicine Centre (ECMC)
National Institute for Health Research Cancer Research Network (NCRN)
Sanofi
Scottish Gynaecological Cancer Trials Group
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”