“I was keen to go on a clinical trial. I wanted to try new cancer treatments and hopefully help future generations.”
A trial looking at chemotherapy after surgery for breast cancer (NEAT)
This trial compared 2 different types of chemotherapy after surgery for breast cancer. This trial was supported by Cancer Research UK.
CMF was the chemotherapy that was most commonly used as adjuvant treatment for early breast cancer. In this trial, doctors wanted to find out if adding another drug called epirubicin to CMF would work better.
You have chemotherapy in cycles of treatment. In this trial, half the women had 6 cycles of CMF, half had 4 cycles of epirubicin, followed by 4 cycles of CMF.
The aim of the trial was to find out which treatment worked best for early stage breast cancer.
Summary of results
The trial team found that a combination of epirubicin and CMF is better than CMF alone as treatment after surgery for early stage breast cancer.
The trial recruited 2,391 women. Of those,
- 1,189 had epirubicin and CMF
- 1,202 had CMF alone
82 out of every 100 women (82%) who had epirubicin and CMF were alive 5 years after treatment.
75 out of every 100 women (75%) who had CMF alone were alive 5 years after treatment. More women in this group had a recurrence of their breast cancer.
The women having epirubicin and CMF had more side effects, particularly hair loss and feeling or being sick. But all other side effects, such as a drop in the number of blood cells, were about the same for both groups.
We have been sent these results by the team who ran the trial. The information they sent us has been reviewed by other independent specialists (
How to join a clinical trial
Dr Helena Earl
Dr Chris Poole
Cancer Research UK
NIHR Clinical Research Network: Cancer
This is Cancer Research UK trial number CRUK/96/003.