A trial looking at liposomal doxorubicin with or without Yondelis for ovarian cancer (ET743-OVA-301)

This large trial was for ovarian cancer that had come back after prior chemotherapy that included a platinum drug. It was comparing liposomal doxorubicin alone with the combination of liposomal doxorubicin (also called Caelyx or Doxil) and Yondelis (also called ET743 or trabectedin).

Doctors usually treat ovarian cancer with surgery and platinum chemotherapy. But sometimes chemotherapy only works for a short time and then the cancer starts to grow again (recurs or relapses).

Liposomal doxorubicin is one of the chemotherapy drugs used to treat ovarian cancer that has come back. Researchers wanted to find out if adding a drug called Yondelis would help women whose ovarian cancer had come back after earlier treatment.