"I am glad that taking part in a trial might help others on their own cancer journey.”
A trial looking at liposomal doxorubicin with or without Yondelis for ovarian cancer (ET743-OVA-301)
This large trial was for ovarian cancer that had come back after prior chemotherapy that included a platinum drug. It was comparing liposomal doxorubicin alone with the combination of liposomal doxorubicin (also called Caelyx or Doxil) and Yondelis (also called ET743 or trabectedin).
Liposomal doxorubicin is one of the chemotherapy drugs used to treat ovarian cancer that has come back. Researchers wanted to find out if adding a drug called Yondelis would help women whose ovarian cancer had come back after earlier treatment.
The aims of this trial were to
- Find out if liposomal doxorubicin with Yondelis is more effective than liposomal doxorubicin alone for ovarian cancer that had come back
- Learn more about the side effects and what happened to the drugs in the body
Summary of results
The researchers found that having both drugs increased the amount of time women were living without any sign of the cancer growing again.
- 663 women had treatment in this trial
- Half had liposomal doxorubicin and Yondelis
- Half had liposomal doxorubicin alone
The researchers looked at how many women responded to treatment. With the combination of both drugs, the cancer responded in 28% of women. With liposomal doxorubicin alone, the cancer responded in 19% of women. By response, they mean the tumour had got smaller or disappeared.
1 in 5 of the women (20%) who had liposomal doxorubicin alone had severe hand foot syndrome, and more than 1 in 10 (11%) had a severe sore mouth. In the group having both drugs, fewer women had these side effects, but more of them had sickness and more severe drops in their blood counts
During follow up, the researchers found the average length of time that women were living without any sign of their cancer growing again was 7.3 months in the group having both drugs and 5.8 months in the group having liposomal doxorubicin alone.
The researchers found that the combination of both drugs was most helpful for women whose cancer had come back 6 months after platinum chemotherapy. For these women, the average length of time before the cancer started growing again was 9.2 months in the group who had both drugs, and 7.5 months in the group who had liposomal doxorubicin alone.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
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Professor Stan Kaye
Experimental Cancer Medicine Centre (ECMC)
Johnson and Johnson Pharmaceutical R+D