
"I am glad that taking part in a trial might help others on their own cancer journey.”
This trial is for people who are going to have surgery to try to cure their cancer.
The urinary tract includes the:
The lining of the urinary tract is called the urothelium, so cancer of the urinary tract is also called urothelial cancer.
Surgery is a common treatment for urinary tract cancer. The type of surgery you have depends on where your cancer started. You might have:
Some people have a higher risk of their cancer coming back after surgery. So researchers are looking for a way to help people in this situation. In this trial, they are looking at a drug called atezolizumab.
Atezolizumab is a type of immunotherapy. It works by blocking a protein that stops the from working properly and attacking cancer cells. Atezolizumab is already a treatment for a number of different types of cancer.
Everyone taking part in this trial has atezolizumab and then surgery.
The main aims of this trial are to find out:
The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join this trial if all of the following apply. You:
Who can’t take part
Cancer related
You cannot join this trial if any of these apply:
Medical conditions
You cannot join this trial if any of these apply. You:
Other
You cannot join this trial if any of these apply. You:
This is a phase 2 trial. Researchers hope that 58 people from the UK, Spain and France will agree to take part.
Everyone taking part has up to 2 doses of atezolizumab before surgery. You have it as a drip into your bloodstream (intravenously). It takes about an hour each time you have it.
After atezolizumab, you have surgery. This is the same as you would have if you weren’t taking part in this trial. The type of surgery you have depends on where your cancer is. Your doctor can tell you more about this.
Research samples
The trial team asks for blood and urine samples. They will use these samples to understand more about how atezolizumab works. Where possible, you have these taken at the same time as your routine blood tests.
You have research samples taken:
The trial team will also ask you for a sample of your cancer that was taken when you had a . And a sample of your cancer taken during the operation. They want to find out more about how atezolizumab affects your cancer.
You see a doctor and have some tests before taking part. The tests you might have include:
You see the trial team before each atezolizumab treatment and before the operation. After surgery, you see the trial team after:
The trial team will also contact you by phone after 1 and 2 years to see how you are.
The trial team monitor you during treatment and afterwards. Contact your advice line or tell your doctor or nurse if any side effects are bad or not getting better.
Atezolizumab can affect the immune system. It may cause inflammation in different parts of the body. This can cause serious side effects. They could happen during treatment, or some months after treatment has finished. Rarely, these side effects could be life threatening. Your doctor or nurse can explain what these side effects are, the risk of them happening and what to look out for. If you have any of these side effects tell your doctor or nurse as soon as possible. You should tell them that you are on or have been on an immunotherapy. |
The most common side effects of atezolizumab are:
We have more information about the side effects of atezolizumab.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Thomas Powles
Queen Mary University of London
Roche
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”