
“I think it’s really important that people keep signing up to these type of trials to push research forward.”
This trial is open to people with a of the urinary tract. It is for people whose aim of their treatment is to control symptoms (
).
The urinary tract includes the:
Squamous cell cancer of the urinary tract is not a common cancer. Researchers are always looking for better treatments for these cancers.
Atezolizumab is an immunotherapy. It works by helping the find and kill cancer cells. Atezolizumab is already used to treat some cancers. This includes some common cancers of the urinary tract but not squamous cell cancers of the urinary tract.
Researchers think that atezolizumab could help people with a squamous cell cancer of the urinary tract.
The main aims of the trial are to find out:
The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join this trial if all of the following apply. You:
Who can’t take part
Cancer related
You cannot join this trial if any of these apply. You:
Medical conditions
You cannot join this trial if any of these apply. You:
You cannot join this trial if any of these apply. You:
This is a phase 2 trial. The team need up to 36 people to take part.
Everyone has atezolizumab. You have it as a drip into a vein once every 4 weeks. This takes less than an hour. Each 4 week period is a .
You can have treatment for up to a year (a maximum of 13 cycles). This is as long as it is helping and the side effects aren’t too bad.
Quality of life
You fill in a questionnaire before starting treatment and then every 12 weeks until your cancer starts to grow again.
The questions ask about:
This is a quality of life questionnaire.
Samples for research
The team ask for a piece of cancer tissue from a previous tissue sample (). They must be able to get this for you to take part in the trial.
You give blood samples during the trial. Where possible the team take these when you have blood taken as part of your routine care. The team use the blood samples to see how well atezolizumab is working.
You see the doctor to have tests before taking part. These include:
You have treatment as an . During treatment you see the doctor every month. This is:
You see the doctor a month after finishing treatment and then every 3 months. This is until your cancer starts to grow again. Your doctor will then tell you how often they want to see you.
You have a CT scan every 3 months while you are in the trial.
The trial team monitor you during treatment and afterwards. Contact your advice line or tell your doctor or nurse if any side effects are bad or not getting better.
Atezolizumab can affect the These side effects could happen during treatment or months after treatment has finished. Rarely, these side effects could be life threatening. Your doctor or nurse can explain what these side effects are, the risk of them happening and what to look out for. |
The most common side effects of atezolizumab are:
We have more about atezolizumab and its side effects.
Your doctor will talk to you about the possible side effects and answer any questions you have before you agree to take part.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Simon Crabb
Cancer Research UK
Roche
University Hospital Southampton NHS Foundation Trust
Southampton Clinical Trials Unit
National Cancer Research Institute (NCRI)
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
“I think it’s really important that people keep signing up to these type of trials to push research forward.”