A trial looking at atezolizumab for cancers of the urinary tract (AURORA)

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you.

Who can take part

You may be able to join this trial if all of the following apply. You:

• have a cancer of the bladder or cancer of the kidneys that is a squamous cell cancer 
• have just been diagnosed or your cancer has got worse 
• have an area of cancer that the doctor can measure on a scan
• are able to have atezolizumab with the intent to control symptoms of your cancer palliative treatment  
• have had no more than 1 course of treatment  that reaches the whole body (systemic treatment)  
• have satisfactory blood test results
• are up and about, can look after yourself but might not be able to work (performance status 0, 1 or 2)
• are willing to use contraception during treatment and for a certain time after if there is any chance you or your partner could become pregnant
• have a tissue sample (biopsy )that the trial team can ask for and get
• are at least 18 years old 

Who can’t take part

Cancer related
You cannot join this trial if any of these apply. You:

• have transitional cell cancer  (TCC) or any part of the cancer is TCC 
• are due to have treatment with the aim to cure 
• have had an immunotherapy . This is apart from BCG for bladder cancer. 
• have had an experimental drug or used a device as part of a clinical trial within 4 weeks of going into the trial
• have or had another cancer unless you have completed all active treatment at least 2 years ago or more. This is apart from successfully treated non melanoma skin cancer , carcinoma in situ (CIS )of the cervix and prostate cancer that was only in the prostate gland (localised )

Medical conditions 
You cannot join this trial if any of these apply. You:

• have major surgery within 30 days of going into the trial
• have had steroids  within 2 weeks of going into the trial. This is apart from certain ones such as inhalers, your doctor will know more about this.
• had a heart attack or unstable angina within the past 6 months. Or any other major heart problem  that could affect you taking part.
• have HIV, active hepatitis B, active hepatitis C or active tuberculosis (TB) 
• have or had an autoimmune disease  . This is apart from certain ones that your doctor will know about.
• have scarring or inflammation of the lung tissue. You can join if this was caused by radiotherapy to the chest or lung. Ask your doctor about this.
• have had a stem cell transplant from another person (allogeneic transplant ) or you have had an organ transplant

You cannot join this trial if any of these apply. You:

• are allergic or sensitive to atezolizumab or any of its ingredients
• have a live vaccine  within 4 weeks of going into the trial. The COVID-19 vaccines aren’t live vaccines. 
• are pregnant or breastfeeding