
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at RAD001 (also called everolimus and Afinitor) for kidney cancer that has spread to other parts of the body.
The most common type of kidney cancer in adults is renal cell cancer. This trial is for people who have a particular type of renal cell cancer called papillary renal cell cancer.
Doctors often treat kidney cancer with interferon and interleukin 2. But doctors are always looking for new ways to treat people with kidney cancer.
Everolimus is a type of treatment called a biological therapy. It works by blocking the action of a protein called mTOR. The mTOR protein controls other proteins that cancer cells need in order to grow. The researchers hope this will help to stop or slow the growth of the cancer.
We know from research that everolimus has helped people with other types of cancer. The researchers think it may also help people with advanced kidney cancer.
The aims of this trial are to find out
You can enter this trial if you
You cannot enter this trial if
This is an international phase 2 trial. It will recruit 12 people in the UK. Everyone taking part in this trial will have everolimus.
Everolimus is a tablet. You take 2 tablets once a day at the same time each day. You take them on an empty stomach or with a light, low fat meal such as cereal with fat free milk, toast or bagel with a fat free spread.
Exactly how long you have treatment for, will depend on your side effects and whether the treatment is still helping to control your cancer.
You cannot eat certain fruits, or drink their juice, while having everolimus. This is because they can interfere with the way it works in your body. These fruits include grapefruit, Seville oranges and star fruit.
You will see the doctor and have some tests before you start treatment. These tests include
You see the doctor
Every 8 weeks you have a CT scan or MRI scan.
The most common side effects of everolimus are
You can find more about everolimus on CancerHelp UK.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Paul Nathan
Experimental Cancer Medicine Centre (ECMC)
Novartis
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.