
"I am glad that taking part in a trial might help others on their own cancer journey.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at tissue samples from people who have cancer of the back passage (rectum) and are having a combination of chemotherapy and radiotherapy (chemoradiation) followed by surgery. The trial aims to learn about gene differences in this cancer.
Treatment for cancer of the back passage (rectal cancer) has greatly improved over the years. But it is important for doctors to find out as much as they can about the tumours so that they can develop new treatments.
It may be possible to improve current treatments by learning more about rectal cancer genes. Genes are coded messages that tell cells how to behave. They control growth and development of the body. But if a gene is changed (mutated) it can make the cell stop working properly and become cancerous.
Doctors in this trial hope to identify differences in certain types of rectal cancer. They will recruit people with rectal cancer who are having
and surgery. If you take part you will give the team permission to study tissue removed when you were diagnosed (biopsy), and during surgery. The aim of this trial is to identify genetic differences in certain types of rectal cancer, which may one day help improve treatment.
You may be able to enter this trial if you
You cannot enter this trial if
This trial will recruit 160 people. Everyone will have an MRI scan before their rectal cancer surgery as planned.
As well as looking at the samples you give, the researchers are looking at how well an MRI scan shows how far rectal cancer has spread. The hospital laboratory will look at the bowel cancer that was removed, to confirm how far it has spread. This is routine. The trial team will then compare this information with that from the MRI scan. This is to see how accurate the MRI scan was in showing how far your cancer had spread before you had surgery.
They will also collect some information about you from your medical notes. They will treat this information , so no one will be able to link the results to you.
You will not need to make any extra hospital visits to take part in this trial.
You will not have any side effects as a result of taking part in this trial.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Prof Gina Brown
Institute of Cancer Research (ICR)
NIHR Clinical Research Network: Cancer
Pelican Cancer Foundation
Royal Marsden NHS Foundation Trust
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”