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A trial of sonidegib for advanced cancer that has got worse despite other treatment

Overview

Cancer types:

All cancer types

Status:

Results

Phase:

Phase 1

Details

This trial looked at a drug called sonidegib (also known as LDE225) for solid tumours that have spread to another part of the body. A solid tumour is any type of cancer apart from or .

Sonidegib is a type of biological therapy. It is a cancer growth blocker. It stops the signals that cancer cells use to divide and grow.

This was the first time that sonidegib was given to patients. The people taking part had different types of advanced cancer that had got worse despite having other treatments. The aims of the trial were to

  • Find the best dose of sonidegib to give

  • Learn more about the side effects and what happens to sonidegib in your body

  • See how well it works for advanced cancer

Recruitment start: 12 March 2009

Recruitment end: 22 September 2011

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Anne Thomas

Supported by

Experimental Cancer Medicine Centre (ECMC)

Novartis

Last reviewed: 26 Feb 2015

CRUK internal database number: 5890

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