
“I was keen to go on a clinical trial. I wanted to try new cancer treatments and hopefully help future generations.”
This trial was looking at capecitabine (Xeloda), with or without lapatinib, for advanced breast cancer.
Doctors usually treat breast cancer with surgery, and one or more of chemotherapy, radiotherapy, hormone therapy or biological therapy. But sometimes these treatments don’t work and the cancer comes back (recurs) or spreads (metastasises) to another part of the body. This is known as advanced, metastatic or secondary breast cancer.
Capecitabine is a chemotherapy drug that was already in use for advanced breast cancer. Lapatinib (GW 572016) was a new drug that was being looked at as a possible treatment for various types of cancer.
There are a number of growth factor receptors on breast cancer cells. When these receptors are triggered, they tell the cell to grow and divide into 2 new cells. Lapatinib targets 2 of these receptors. The first is called erbB1, or epidermal growth factor receptor (EGFR). The second is called erbB2, or HER2/neu receptor. Doctors hoped that by targeting 2 different receptors at the same time, the drug would be better at treating breast cancer. But they didn’t know for sure how well it would work.
The aim of this trial was to compare capecitabine alone to capecitabine and lapatinib to see which was better for advanced breast cancer.
The researchers found that advanced breast cancer responded to capecitabine and lapatinib more often than it responded to capecitabine alone. And in women who had both drugs, it took longer for the cancer to start growing again.
This was a randomised trial.
The researchers looked at how many women responded to the treatment. For the group having both drugs,
In the group of women who had capecitabine alone, there were no complete responses, and 28 partial responses.
Most of the women in both groups had some side effects. Side effects such as diarrhoea, sickness and a rash happened more often in the group of women who had both drugs.
The researchers found that the average time it took for the cancer to start growing again was
We have based this summary on information from the team who ran the trial. As far as we are aware, the information they sent us has not been reviewed independently () or published in a medical journal yet. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Rob Coleman
Cancer Research UK
GlaxoSmithKline (GSK)
National Institute for Health Research Cancer Research Network (NCRN)
This is Cancer Research UK trial number CRUKE/05/027.
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
“I was keen to go on a clinical trial. I wanted to try new cancer treatments and hopefully help future generations.”