
"I am glad that taking part in a trial might help others on their own cancer journey.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at a chemotherapy drug called cabazitaxel for transitional cell cancer of the bladder or urinary system. It is for people who have cancer that has spread and has got worse despite having chemotherapy with a .
Transitional cell cancer (TCC) is the most common type of bladder cancer. Transitional cells (also called urothelial cells) line the urinary system so you can also get TCC in the kidney, ureters or .
If transitional cell cancer has spread into surrounding tissue or to another part of your body, doctors usually treat it with chemotherapy. They often use platinum chemotherapy drugs such as cisplatin or carboplatin. But the cancer can come back or get worse after having this type of chemotherapy. If this happens, you may have more chemotherapy. But researchers are looking for new treatments to help people in this situation.
In this trial, they are looking at a chemotherapy drug called cabazitaxel, which is already used to treat other types of cancer such as prostate cancer. The aim of the trial is to see if cabazitaxel helps people with transitional cell cancer that has spread and has got worse despite having platinum chemotherapy.
You may be able to enter this trial if
You cannot enter this trial if you
This phase 2 trial aims to recruit 96 people. It is a randomised trial. The people taking part are put into treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in.
People in one group have cabazitaxel through a drip into a vein once every 3 weeks. Each 3 week period is called a cycle of treatment. As long as you don’t have bad side effects, you can have up to 6 cycles of treatment.
People in the other group have whatever treatment their doctor thinks would be best to relieve their symptoms. This is called . It may include having other chemotherapy drugs, but not cabazitaxel.
The trial team will ask you to fill out a questionnaire before you start treatment, every 3 weeks during your treatment and when you finish treatment. The questionnaire will ask about side effects and how you’ve been feeling. This is called a quality of life study.
You see the trial team and have some tests before you start treatment. The tests include
If you are in the group having cabazitaxel, you go to hospital once every 3 weeks to have treatment. It takes about an hour each time.
If you are in the other group, the number of hospital visits you have will depend on your treatment. Your doctor will explain this to you.
Everybody taking part has a CT scan or MRI scan after about 9 weeks of treatment.
When you finish treatment, you see the trial team 3 weeks later. You have a physical examination, blood tests and another CT or MRI scan. You then see them every 3 months for up to 2 years.
The side effects of cabazitaxel include
If you are in the best supportive care group, your doctor will explain the possible side effects of any treatment.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Anjali Zarkar
Sanofi
University Hospital Birmingham NHS Foundation Trust
University of Warwick
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”