A trial looking at AUY922 for stomach cancer that has spread

This trial is looking at a drug called AUY922 for stomach cancer that has spread to other parts of the body (advanced stomach cancer).

Doctors often treat advanced stomach cancer with chemotherapy. But the cancer can come back again after treatment. If this happens, you may have more chemotherapy, but researchers are looking for new treatments to help people in this situation. In this trial, they are looking at a new drug called AUY922.

We know from laboratory research that AUY922 can block the activity of an enzyme called ATPase. ATPase is involved when cells divide. Blocking it may stop cancer cells growing.

In this trial, researchers will compare AUY922 with the chemotherapy drugs docetaxel and irinotecan. The aims of the trial are to

• See if AUY922 helps people with advanced stomach cancer more than one of the chemotherapy drugs

• Find out more about AUY922 and what happens to it in the body

• Learn more about the side effects