Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A trial of arsenic trioxide (Trisenox) for myelodysplastic syndromes
This trial was looking at arsenic trioxide (also called Trisenox) for myelodysplastic syndromes.
Myelodysplastic syndromes (MDS) are a group of diseases. In MDS too many blood cells are made by the
If you have MDS but don’t have any symptoms, you may not have treatment straight away. But if you do have symptoms, you may have treatment with chemotherapy, or you may have supportive care. Supportive care means controlling the symptoms rather than treating the MDS itself. This includes treatments such as blood or platelet transfusions, antibiotics or injections of
Arsenic Trioxide was a treatment that had been used for a type of leukaemia called acute promyelocytic leukaemia. Doctors thought it might also help people with MDS. The aims of the trial were to
- See how well arsenic trioxide worked for MDS
- Learn more about the side effects
Summary of results
The trial team found that arsenic trioxide helped about 1 in 5 people with MDS and there were not too many side effects.
- The trial recruited 115 people with MDS
- 64 people had high risk MDS
- 50 people had low risk MDS
- Doctors were not able to assess the risk for one person
People taking part had the arsenic trioxide as an injection every day for five days and then twice a week for 15 weeks.
Results of blood tests and bone marrow tests showed that MDS responded to the treatment in 11 of the people with high risk MDS and 13 of the people with low risk MDS.
Of the people who had needed to have
The researchers found that the responses to treatment lasted on average just under 3 and a half months after the injections finished.
The most common side effect was a drop in the number of blood cells, but this may have been due to the MDS, rather than the treatment.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Professor Alan Burnett
Cell Therapeutics Inc (CTI)