
"I am glad that taking part in a trial might help others on their own cancer journey.”
This trial was looking at a drug called motesanib with paclitaxel and carboplatin for non small cell lung cancer (NSCLC). The people taking part had NSCLC that had spread to another part of the body (advanced cancer) and was either an adenocarcinoma or large cell carcinoma type.
If you have advanced NSCLC you may have chemotherapy to control the growth of your cancer, and to relieve symptoms. Your doctor may recommend you have drugs called paclitaxel and carboplatin, which is a . But unfortunately this does not work for everyone and researchers are always looking for ways to improve treatment.
Motesanib is a type of biological therapy that aims to block the growth of blood vessels in cancers. When a cancer reaches a certain size, it needs to grow blood vessels to get oxygen and food so that it can continue to grow.
Doctors wanted to find out if motesanib and chemotherapy was better than chemotherapy alone for advanced NSCLC.
The aims of this trial were to
The trial team found that motesanib with carboplatin and paclitaxel didn’t help people with advanced non small cell lung cancer live longer.
This was a phase 3 trial. It recruited 1,090 people. It was a randomised trial. The people taking part were put into treatment groups. Neither they nor their doctor could choose which group they were in.
Half the people had carboplatin, paclitaxel and motesanib. The other half had carboplatin, paclitaxel and a dummy drug.
The researchers found that the average overall length of time that people lived after treatment was
Although there is a small difference between the 2 groups, this could have happened by chance (the results were not ).
Between the 2 groups there was little difference in the time it took for the cancer to start getting worse.
The most common side effects of chemotherapy and motesanib were
The trial team concluded that adding motesanib to chemotherapy didn’t help people with NSCLC to live significantly longer.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists () and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Charles Brigden
Amgen
Experimental Cancer Medicine Centre (ECMC)
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”