A study using a quick scan to spot prostate cancer early (ReIMAGINE Prostate Cancer Screening)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Prostate cancer





This study is looking at an MRI scan to check for abnormal areas in the prostate that might be cancer. The study is for men who:

  • haven’t been previously diagnosed with prostate cancer
  • are between 50 and 75 years old

More about this trial

The National Institute for Health and Care Excellence (NICE) in the UK recommend an MRI scan as one of the first tests if you are referred to hospital with suspected prostate cancer. The scan takes about 40 minutes. And you have an injection of contrast dye to show up the prostate gland more clearly. 

The MRI result tells the doctor whether it is necessary to take tissue samples (a biopsy) from the prostate. And where to take the samples from.  

In this study, they are testing if it’s worth checking men for possible signs of prostate cancer, even if they don’t have symptoms. To do this, they are using a quick MRI scan that takes 10 minutes. It is a simpler version of the longer scan and you don’t need to have an injection.

The scan takes some extra pictures of the prostate. This is to check if the information from the scan can predict abnormalities without having to be interpreted by a specialist doctor (a radiologist). This adds another 5 to 10 minutes to the scan. 

You’ll be sent a letter inviting you to join via participating GP practices.  

The main aims of this study are to find out:

  • if men are willing to join
  • how acceptable they find the scan
  • how well the MRI scan picks up possible signs of prostate cancer 
  • more about the cost

Please note, there may not be a direct benefit if you take part in this study. But some men will be advised to have more detailed tests for prostate cancer and it might help other men with prostate cancer in the future.      

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this study if all of the following apply. 

You are:

  • male 
  • between 50 and 75 years old 

Who can’t take part

You cannot join this study if any of these apply.

  • have had prostate cancer in the past 
  • have a fear of enclosed spaces or you can’t have an MRI due to a pace maker, metal clips in the brain or another implant
  • live in a care home or need a lot of help at home
  • have dementia, or similar issues with your brain or nervous system that mean you cannot understand and consent to the study

Trial design

This feasibility study is taking place in London. The study team want to check if it is possible to do the study before they run a larger trial.

They hope to find 300 men to take part. They send a letter via participating GP practices. It is not possible to join the study by asking the team directly as they need to know how many men would respond to a random GP invitation.

If you are contacted and agree to take part, the study team will arrange an appointment at University College Hospital in London. At the appointment:

  • they ask about your medical history
  • you give a blood sample for PSA testing 
  • you have the MRI scan

2 specialist doctors (radiologists) will look at the scan. The study doctors should have these results within 2 weeks. They check the result and compare it with the PSA blood test result. 

They send a letter to you and your GP detailing the results. This letter will advise whether they think you are ‘at risk’ of prostate cancer or ‘not at risk’.

What happens next

  • Men not at risk of prostate cancer won’t need further tests or follow up for prostate cancer
  • Men at risk of having prostate cancer – the study team will recommend your GP refers you to hospital to have a more detailed MRI scan 

The study team will ask to collect reports and results of scans and other tests you might have. 

Hospital visits

You have 1 hospital visit to have the scan and a blood test. This takes about 2 hours. 

The study team will pay up to £30 travel expenses for this visit. 

Side effects

You might have discomfort and bruising after the blood test, but this should clear up quickly. 

An MRI is very safe and doesn’t use radiation. 

Some people may have symptoms of claustrophobia from lying in a confined space. You can alert the staff at any time during the scan by pressing a buzzer. And you can talk to them through the headphones provided. 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Caroline Moore
Professor Mark Emberton

Supported by

University College London (UCL)
Cancer Research UK
Medical Research Council (MRC)

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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