A study of unrelated cord blood transplants for people with cancers of the blood or lymphatic system

Cancer type:

Acute leukaemia
Blood cancers
Chronic leukaemia
Hodgkin lymphoma
Myelodysplastic syndrome (MDS)
Non-Hodgkin lymphoma




Phase 2

This study was looking at using umbilical cord blood from unrelated donors for people who have leukaemia, lymphoma or myelodysplastic syndrome.

If you have leukaemia Open a glossary item, lymphoma Open a glossary item or myelodysplastic syndrome (MDS) Open a glossary item and your doctors think there is a high risk of your disease coming back after treatment, they may suggest you have a bone marrow or stem cell transplant using cells from a donor.

A donor must have similar bone marrow Open a glossary item to you. Some people have a brother or sister who is a match. Other people have a transplant from an unrelated donor. But sometimes, neither type of donor is available. This study was for people in that situation.

Stem cells Open a glossary item are cells in the bone marrow that grow into new blood cells. Stem cells can be collected from the umbilical cords of newborn babies. Many people around the world have donated their baby’s umbilical cords and a number of young children have been treated using these cells. Researchers had also started to use this type of treatment for adults.

Before a transplant, you have chemotherapy sometimes with radiotherapy. This is called conditioning. In this study, researchers were using unrelated cord blood to treat adults having 1 of 3 different types of conditioning.

The aims of the study were to see if this treatment is possible (a pilot study) and safe, and whether it helps people who need a transplant but don’t have a suitable adult donor.

Summary of results

This trial was never finished so there are no results available. The researchers were unable to recruit enough patients.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Prof Antonio Pagliuca

Supported by

Experimental Cancer Medicine Centre (ECMC)
Kings College Hospital NHS Foundation Trust

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 6403

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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