
“I think it’s really important that people keep signing up to these type of trials to push research forward.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking to see if it is possible to take tissue samples during surgery to remove pancreatic cancer.
The study is taking place at Addenbrooke’s Hospital in Cambridge.
Pancreatic cancer can be difficult to treat. The usual treatments are surgery and chemotherapy. But immunotherapy doesn’t work very well. So, researchers are running this study to work out why.
Before the researchers can run a large study, they need to do a small study to see if it’s possible to do it well. This is called a feasibility study.
Some people have an operation called a Whipple’s procedure to remove pancreatic cancer. In this study, researchers plan to look at which parts of the immune system are present in the cancer and the surrounding tissues. This is called the ‘tumour immune milieu’.
Before the operation, the surgeon stops the blood supply to the pancreas. This can change what parts of the immune system are within the cancer and in the surrounding tissue.
So, the researchers will see if it’s possible to take the tissue samples (biopsies) before the blood supply to the cancer is stopped. They’ll compare these samples with samples leftover after the operation.
The main aims of this study are to find out:
Please note – you won’t benefit as a result of taking part in this study. But the information collected might help to better understand pancreatic cancer and benefit patients in the future.
The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join this study if all of the following apply. You:
Who can’t take part
You:
This is a feasibility study. The researchers need 10 people to take part. It is for people who are having surgery at Addenbrooke’s Hospital in Cambridge.
The study team will check your medical notes for information on your past and present health, and for information about your cancer.
Samples for research
You give some extra blood samples before and on the day of surgery. Where possible you give these at the same time as routine blood samples.
If possible, the doctors will take a tumour sample during surgery. They take this just before you have the pancreas removed. They plan to look:
You see a doctor who explains the study to you. You have a chance to ask any questions. After that you sign a consent form if you agree to take part. This visit will take about 1½ hours. You are free to change your mind at any time if you don’t want to take part after all.
There shouldn’t be any extra side effects as a result of taking part in this study.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Duncan Jodrell
AstraZeneca
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge
Freephone 0808 800 4040
“I think it’s really important that people keep signing up to these type of trials to push research forward.”