A study to increase the reliability and accuracy of MRI scanning in cancer (QuIBs)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Brain (and spinal cord) tumours
Ewing's sarcoma
Head and neck cancers
Laryngeal cancer
Liver cancer
Lung cancer
Melanoma
Mouth (oral) cancer
Nasal and paranasal sinus cancer
Nasopharyngeal cancer
Non small cell lung cancer
Pharyngeal cancer
Salivary gland cancer
Sarcoma
Small cell lung cancer
Soft tissue sarcoma

Status:

Closed

Phase:

Other

This study is open to people who are outpatients of The Christie Hospital, Manchester. It is for people with one of the following cancers:

  • liver cancer
  • melanoma
  • soft tissue sarcoma
  • brain tumour
  • head and neck cancer
  • lung cancer

More about this trial

Doctors use magnetic resonance imaging scans (MRI) to diagnose cancer. They can also use them to see how well cancer is responding to treatment. As MRI scans become better they are used more often in treatment and clinical trials. 

In this study researchers want to test new MRI imaging. And new ways to analyse the images which are being developed in Manchester. They want to try and increase understanding of how cancer cells grow and divide (cancer biology). In particular, the reliability of new techniques might depend on:

  • the type of cancer 
  • where the cancer is in the body
  • the new ways to get the information from the images

They will take MRI scans of people with different cancer types and look at the way the scan is done. 

The researchers hope by doing this, they can work out the best way to scan. So that in the future people can have the most appropriate and reliable scan. Whether they are in a clinical trial or having treatment.   

Who can enter

The following bullet points list the entry conditions for this study Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

You may be able to join this study if you are an outpatient at The Christie Hospital, Manchester and you have one of the following

And all of the following apply

  • Your cancer is stable
  • If you are to start treatment, it is a standard treatment Open a glossary item for your cancer
  • You are able to lie still comfortably for up to an hour
  • You have satisfactory blood test results
  • You are at least 18 years old

You cannot join this study if any of these apply. You

  • Aren’t able to have an MRI scan. For example you have a pacemaker, metal plate or any other metal in your body 
  • Have asthma 
  • Are allergic to the contrast medium used or any of its ingredients
  • Are pregnant or breastfeeding

Trial design

The researchers needs up to 450 people to join this study. 

At one of your routine clinic appointments the doctor talks to you about the study. They give you an information sheet to take home and read. A few days later a member of the study team phones you to ask if you are interested in taking part. 

As part of the study you have one or more MRI scans. 

Before the scan the researcher might ask you to have an injection of a dye (a contrast medium). You don’t have to have the injection. You can still take part in the study.

Hospital visits

You have the MRI scan at the University of Manchester. 

There are no extra hospital visits if you take part in the study.

Side effects

The side effects of the contrast medium are mostly mild. They include a metallic taste in the mouth and feeling sick. 

We have information on MRI scans.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Alan Jackson

Supported by

Experimental Cancer Medicine Centre (ECMC)
University of Manchester

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

12794

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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