A study to find out why certain people develop oesophageal cancer (ChOPIN)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Oesophageal cancer





This study is looking at whether your genes affect your risk of developing cancer of the food pipe (oesophageal cancer). You can take part if you have Barrett’s oesophagus or oesophageal cancer. You can also take part if you have inflammation of the oesophagus (oesophagitis) caused by long term acid indigestion (reflux) or hiatus hernia.

More about this trial

There are several risk factors for oesophageal cancer. These include things such as lifestyle, the environment or genetic makeup Open a glossary item.

This study will collect blood samples from people who have reflux (also called erosive) oesophagitis, Barrett’s oesophagus or oesophageal cancer to study their DNA Open a glossary item. Researchers have already identified some genes that may affect the risk of oesophageal cancer, but they want to learn more.

In this study, the researchers will collect blood samples from people to help find out possible causes of oesophageal cancer that are related to their genes.

The aims of the study are to find out why

  • Some people develop Barrett’s oesophagus
  • Some people with Barrett’s oesophagus then develop oesophageal cancer

You won’t get any direct benefit from taking part in this trial, nor will it affect any treatment you have. But it will help researchers find out more about the genetic causes of oesophageal cancer.

Who can enter

You can enter this trial if you

  • Have been diagnosed with reflux oesophagitis, Barrett’s oesophagus, hiatus hernia or oesophageal cancer
  • Are willing to give a blood sample
  • Are at least 18 years old

Trial design

You will have a 2 blood samples taken about 3 years apart during a routine hospital visit.

Hospital visits

You will have your blood tests at the hospital, during an outpatient appointment. You will not have to make an extra trip.

Your treatment and hospital appointments will carry on as normal.

Side effects

As there are no treatments involved in this trial, the only side effect you may have is a small bruise when the blood sample is taken.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Janusz Jankowski

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
University Hospitals Plymouth NHS Trust
Plymouth University Peninsula Schools for Medicine and Dentistry
Wellcome Trust

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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