
"I am glad that taking part in a trial might help others on their own cancer journey.”
The aim of this study is to learn more about early stage and lymphoproliferative disorders.
Researchers would like to look at the differences between:
Lymphocytes are a type of white blood cell. They form part of your . Lymphoproliferative disorders start when there is a problem with the growth or development of lymphocytes.
Most people with these early stage conditions do not have any serious problems with their health. But a small number of people go on to develop blood cancer or cancer.
At the moment, we don’t know which people with early stage conditions are more likely to go on to develop one of these cancers. The study team aim to find out more about factors which could help them to predict who might go on to develop cancer.
The researchers think these factors could include:
The other aims of the study are to find out:
In the future, results of this trial might help doctors identify:
It might also help doctors reassure people whose lymphoproliferative disorder is unlikely to get worse.
In the future the information might also help doctors develop new treatments for blood and bone marrow cancers.
Please note - you won’t get any direct benefit from taking part in this study, nor will it affect any treatment you have. But may it help people in the future.
The following bullet points are a summary of the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
Who can take part
You are put into one of three groups depending on your type of lymphoproliferative disorder.
You can take part if you have been diagnosed in the last 3 years with one of the following:
And if all of the following apply. You:
Who can’t take part
You cannot join this study if any of these apply. You:
The study team would like around 1,650 people to take part.
You are put into one of three groups depending on your type of lymphoproliferative disorder. This is because the tests, and samples you give, are slightly different for each group.
Group 1
Group 2
Group 3
Everyone gives samples during the study.
These samples might include:
Doctors and scientists will look at samples from people whose condition has progressed over the course of the study. They compare these samples to people whose condition has stayed the same (stable).
Quality of life
The study team will ask you to fill out a questionnaire each time you meet with them. You are also asked to fill out a questionnaire if your condition progresses.
The questionnaires will ask about side effects and how you’ve been feeling. This is called a quality of life study.
You continue to have your usual monitoring while taking part in the study. This means if you are having a telephone or face-to-face appointment with your specialist every 6 to12 months this will carry on. Or if you usually just see your GP, this will continue.
Any hospital visits as part of the study are extra to your usual care.
You see the study team and have some tests before you join the study. The tests include:
The study team will call you after one year to check you are still happy to take part and answer any questions.
You see the study team 2 years after your first visit. And then 5 years after your first visit. You have some tests at these visits. These include:
The study team ask you about any new medications and check how you are getting on.
For some people, the study will have closed before they get to their 5 year visit. The study team will write to you and let you know that you don’t need to come to any more appointments if this is the case.
Condition progression visit
The study team would like to see you if your condition progresses while you are taking part. You might find out about the progression from one of the study tests. Or as part of your routine care. The team will check how you are getting on.
You also have some tests. These depend on the type of lymphoproliferative disorder you have and what group you are in. They might include:
It’s likely you will have finished taking part in the study after your condition progression visit. If you still do not need treatment at this point and you’re still happy to take part in the study, the study team will explain what will happen.
Extra bone marrow samples
The study team will ask if you are happy to give extra bone marrow samples for the study. This would be at your first visit and at your progression visit (if you have one). These samples give researchers more information about the progression of lymphoproliferative disorders.
The extra tests you have as part of the study are common and safe tests.
It’s possible you might have some possible bleeding or bruising from the blood samples.
The most common side effect of having a bone marrow test is some pain. Your doctor gives you some to try and prevent this.
An MRI is very safe and doesn’t use radiation. Some people can’t have an MRI but the checklist picks this up beforehand. Allergic reactions to the dye used in an MRI is rare.
A CT scan is a safe test for most people. Your doctor and radiographer make sure the benefits of having the test outweigh these risks. Exposure to radiation during a CT scan can slightly increase your risk of developing cancer in the after many years. Talk to your doctor if this worries you.
We have detailed information on the following tests and scans, including possible risks and side effects:
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Anna Schuh
Janssen
University of Oxford
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”