A study to find a new way to diagnose cancer of the ovaries and womb (CTCR OV05)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Ovarian cancer
Womb (uterine or endometrial) cancer





This study is looking at finding a new way to diagnose cancer of the ovaries and lining of the womb (endometrial cancer).  

This study is open to women have been referred to Addenbrooke’s Hospital because they may have ovarian cancer. And for women who are having surgery at Addenbrooke’s Hospital to remove ovarian cancer or endometrial cancer.

More about this trial

Doctors use a blood test called CA125 followed by a transvaginal ultrasound scan to diagnose ovarian cancer. They also use a transvaginal ultrasound to diagnose endometrial cancer and they may take a small piece of tissue (biopsy Open a glossary item) of the womb. 

We know from research that small pieces of DNA Open a glossary item from these cancers can be found in the blood. We also know that women with these cancers also have certain changes in the mucus Open a glossary item of their cervix. 

In this study the researchers want to find out if doctors can use these samples to better diagnose and treat these cancers. 

To do this they first need to know if it is possible to find these changes in the blood and the mucus of the cervix of women when they are diagnosed with these cancers.

Who can enter

You may be able to join this study if you are woman who is at least 18 years old and one of the following apply

  • Your GP has referred you to the clinic at Addenbrooke’s Hospital because you may have ovarian cancer
  • You are having surgery at Addenbrooke’s Hospital to find out if you have either ovarian cancer or endometrial cancer

Trial design

This is a feasibility study. The researchers need 230 women to join. 

The study team will ask for some blood samples, a cervical smear Open a glossary item and mucus Open a glossary item samples from your cervix. For women whose GP has referred them, the researchers will take these at your routine clinic appointment. 

For women who are having surgery to remove their cancer, your surgeon will take the cervical smear and mucus samples during the operation. The researchers will take a blood sample before your operation and then every day you are in hospital after your operation.

Hospital visits

There are no extra hospital visits if you take part in the study.

Side effects

You may feel some discomfort and have a slight bruising where the blood samples were taken.

Taking the mucus samples is the same as having a cervical smear test.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Elizabeth Moore

Supported by

Cambridge University Hospitals NHS Foundation Trust
Medical Research Council (MRC)
Target Ovarian Cancer
University of Cambridge


Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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