A study to develop a screening test for bowel cancer (NIL)

Cancer type:

Bowel (colorectal) cancer





This study is looking at using neurotensin and IL-8 to screen for bowel cancer and bowel polyps Open a glossary item

It is open to people who are having a colonoscopy Open a glossary item at Lancashire Teaching Hospitals or University Hospitals of Morecambe Bay.

More about this trial

The FIT test is a screening test for bowel cancer. This test looks for very small amounts of blood in your poo. If there are small amounts detected you might have a colonoscopy

Your GP might also refer you to a specialist at the hospital if you have possible symptoms of bowel cancer. They do this through an urgent referral. The specialist will arrange for you to have tests. One test might be a colonoscopy.

Researchers think they can measure substances in the blood to find out if you might have:

  • bowel cancer
  • large bowel polyps. 

These substances are neurotensin and I-L8.

They want to develop a test using these substances to screen for bowel cancer and large bowel polyps. And the researchers think this might be a better and quicker way to screen for bowel cancer.

The aims of this study are to develop a screening test and find out well it works.

Who can enter

The following bullet points are a summary of the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this study if you are to have a colonoscopy at Lancashire Teaching Hospitals or University Hospitals of Morecambe Bay. 

Who can’t take part

You cannot join this study if any of these apply. You:

  • need to have emergency surgery 
  • have an inflammatory bowel disease such as Crohn’s
  • have had bowel cancer caused by an inherited condition such as Lynch syndrome Open a glossary item (HNPCC) or familial adenomatous polyposis  Open a glossary item(FAP
  • have had another cancer
  • had cancer that has spread to the liver 
  • had a previous colonoscopy that showed there was no cancer  
  • have any other medical condition or mental health problem that could affect you taking part

Trial design

The team need 500 people to join the study.

When you have your colonoscopy the team take a blood sample. They give the sample a unique code so no one knows whose it is. They test the sample for the amounts of neurotensin and IL-8. 

The team will also look at your medical records for information such as:

  • your age
  • your gender
  • your height and weight 
  • any other medical conditions

Hospital visits

There are no extra visits if you take part in this study.

Side effects

There are no side effects from taking part in this study.

We have information on having a colonoscopy.



Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Mr Georgios Sgourakis

Supported by

Rosemere Cancer Foundation
University Hospitals of Morecambe Bay NHS Foundation Trust
Lancashire Teaching Hospitals NHS Trust

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Alan took part in a clinical trial for bowel cancer patients

A picture of ALan

“I think it’s essential that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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