Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A study to collect tissue and blood samples from people in clinical trials (CALIBRATE)
This study is collecting cancer tissue and blood samples from people who are taking part in a cancer clinical trial. Researchers want to see if they can find a new way to see how well cancer treatment works.
More about this trial
Doctors take a small piece of cancer tissue (
In this study they will take blood samples before, during and after treatment to see if they can see a change in the ctDNA. Changes in the ctDNA might be able to tell them whether treatment is working or not.
The team also want to:
- find how safe it is to take tissue samples from people who are having experimental treatment as part of a clinical trial
- ask you your opinion about taking research samples in clinical trials
Who can enter
You may be able to join this study if all of the following apply. You
- Have cancer and are going to the Addenbrooke’s hospital in Cambridge
- Are thinking of taking part in a clinical trial that is using an experimental drug
- Are at least 18 years old
You cannot join this study if you have a medical or mental health condition that the study team think could affect you taking part.
The study team need 200 people to join.
The study team will take some extra blood samples from you before, during and after your treatment as part of the clinical trial. They will ask for a sample of your cancer that was removed when you had surgery or a
The team will ask if you are willing to have biopsies done during the study. This is so they can obtain fresh samples of your cancer tissue. They will also ask if you are willing to fill in 2 questionnaires. The questionnaires will ask you your opinions about research samples taken as part of a clinical trial. You can agree to do both, only one or neither. Either way you can still take part in the main study.
The research team will take the blood samples when you have your routine bloods done for the clinical trial.
If you agree to have the biopsies done, they will try to arrange them at the same time as your routine hospital appointments. The trial team can let you know what having a biopsy will involve.
You may have some discomfort, bruising and slight bleeding from the blood samples.
Taking a biopsy is a safe procedure. You may have some discomfort, bruising and slight bleeding.
How to join a clinical trial
Dr Richard Baird
Addenbrookes Charitable Trust (ACT)
Cambridge Clinical Trials Unit - Cancer Theme
Cambridge University Hospitals NHS Foundation Trust
NIHR Clinical Research Network: Cancer
University of Cambridge