A study to collect tissue and blood samples from people in clinical trials (CALIBRATE)

Cancer type:

All cancer types

Status:

Open

Phase:

Other

This study is collecting cancer tissue and blood samples from people who are taking part in a cancer clinical trial. Researchers want to see if they can find a new way to see how well cancer treatment works.

More about this trial

Doctors take a small piece of cancer tissue (biopsy Open a glossary item) to find out more about the cancer cells. One thing they look at is how cancer may respond to treatment. Circulating tumour DNAs (ctDNAs) are small pieces of cancer cell DNA Open a glossary item that are in the blood stream. This DNA is released into the bloodstream by dying cancer cells. The researchers think looking at ctDNAs can also show how well the cancer is responding to treatment.

In this study they will take blood samples before, during and after treatment to see if they can see a change in the ctDNA. Changes in the ctDNA might be able to tell them whether treatment is working or not.

The team also want to:

  • find how safe it is to take tissue samples from people who are having experimental treatment as part of a clinical trial
  • ask you your opinion about taking research samples in clinical trials

Who can enter

You may be able to join this study if all of the following apply. You

  • Have cancer and are going to the Addenbrooke’s hospital in Cambridge
  • Are thinking of taking part in a clinical trial that is using an experimental drug
  • Are at least 18 years old

You cannot join this study if you have a medical or mental health condition that the study team think could affect you taking part.

Trial design

The study team need 200 people to join.

The study team will take some extra blood samples from you before, during and after your treatment as part of the clinical trial. They will ask for a sample of your cancer that was removed when you had surgery or a biopsy Open a glossary item.

The team will ask if you are willing to have biopsies done during the study. This is so they can obtain fresh samples of your cancer tissue. They will also ask if you are willing to fill in 2 questionnaires. The questionnaires will ask you your opinions about research samples taken as part of a clinical trial. You can agree to do both, only one or neither. Either way you can still take part in the main study.

Hospital visits

The research team will take the blood samples when you have your routine bloods done for the clinical trial.

If you agree to have the biopsies done, they will try to arrange them at the same time as your routine hospital appointments. The trial team can let you know what having a biopsy will involve.

Side effects

You may have some discomfort, bruising and slight bleeding from the blood samples.

Taking a biopsy is a safe procedure. You may have some discomfort, bruising and slight bleeding.

Location

Cambridge

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Richard Baird

Supported by

Addenbrookes Charitable Trust (ACT)
AstraZeneca
​Cambridge Clinical Trials Unit - Cancer Theme
Cambridge University Hospitals NHS Foundation Trust
NIHR Clinical Research Network: Cancer
University of Cambridge

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

13303

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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