
"He went through six operations and was placed on a clinical trial so he could try new treatments.”
This study is collecting blood and tissue samples from people who have a . A glioma is a type of brain tumour.
It is part of a larger research programme to learn more about gliomas and improve treatment.
Surgery is the main treatment for glioma. This might be followed by chemotherapy and or radiotherapy.
Sometimes it is difficult to remove all the tumour with surgery because of where it is in the brain. So some cancer cells might be left behind and the tumour can start to grow again. Radiotherapy and or chemotherapy can delay this but sometimes only for a short time. So doctors want to develop and test new treatments for glioma.
To do this, researchers are starting by collecting blood and tissue samples. They will look at the samples to find out more about the individual make up of gliomas. This is called molecular or genetic profiling. The researchers hope that in the future it will help doctors decide the best treatment for everyone based on the genetic make up of their cancer. This is called personalised medicine.
The main aims of this study are to:
Please note you may not get any direct benefit from taking part. The researchers hope that what they learn from this study might help doctors improve treatment for glioma. You might benefit if you are told about possible treatments or research studies.
The following bullet points are a summary of the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join this study if all of the following apply. You:
Who can’t take part
You cannot join this study if any of these apply. You:
This is a feasibility study. The study team need 1,000 people to take part.
You give a blood sample for the study. You might be asked to have more blood samples taken during your treatment for the study. You can say no to these samples if you don’t want to give them.
The team also ask to have a sample of tissue removed during surgery or from a previous surgery.
Your tumour will be analysed by a at the hospital as usual. A small piece will be sent for review by experts. They plan to look at the
and for substances called
.
The results of the detailed analysis will be sent back to your doctor. The aim is for this to be done within 28 days. It will take longer as the new testing is introduced across the study sites. This analysis could detect inherited cancer genes that may also affect your family. You will be told about these if you provide to do so when you join the study.
They will also analyse any samples of fluid from around the brain and spinal cord that you have taken. This is and doctors sometimes collect this as part of your routine care.
After surgery you continue to have standard treatment. This could include radiotherapy and chemotherapy. Your doctor will discuss this with you.
The study team collect information about your glioma. This includes details about:
Quality of life
The study team ask you to fill out a questionnaire:
The questionnaire asks about side effects and how you’ve been feeling. This is called a quality of life study.
Sub studies
You will also be asked to join a sub study, called BRIAN, run by The Brain Tumour Charity. This allows people to record their experiences of having a brain tumour. This is to help doctors and researchers get a better understanding of how having a brain tumour affects the quality of life of people:
Your doctor will talk to you about joining this extra study. They hope in the future this information will help provide better care and support to patients and their families.
The study team may also ask if you want to join another study called PEACE if it is running at your hospital. This study is asking people to agree to have samples taken of their cancer after their death. It is for people who have a brain tumour or a solid tumour cancer that has spread elsewhere in the body. They hope this will help them understand:
You don’t have any extra hospital visits or scans if you take part in this study.
There are no side effects apart from some possible slight bleeding or bruising from the blood samples.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Colin Watts
Cancer Research UK Clinical Trials Unit, Birmingham
Genomics England
The Brain Tumour Charity
University of Birmingham
University of Oxford
University of Edinburgh
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
"He went through six operations and was placed on a clinical trial so he could try new treatments.”