A study of the link between womb cancer and Lynch syndrome (PETALS)

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Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Womb (uterine or endometrial) cancer



This study is looking at how many womb cancers are due to Lynch syndrome. It is open to women with womb (endometrial) cancer who are going to the St Mary’s Hospital in Manchester.

More about this trial

Women can have an increased risk of developing womb cancer for a number of reasons including

  • Age - this type of cancer is more common in older women
  • Being very overweight
  • Not having children

Another risk factor is having an inherited Open a glossary item fault in certain genes (mutations Open a glossary item) that protects against cancers. One such fault can lead to Lynch syndrome.

People who have Lynch syndrome Open a glossary item(also known as HNPCC) have an increased chance of developing certain cancers including womb cancer and bowel cancer.

When someone has Lynch syndrome they are offered yearly bowel screening to remove any small growths (called bowel polyps Open a glossary item) that may become cancer.

Researchers don’t know how many women with womb cancer also have Lynch syndrome. And if these women knew they had Lynch syndrome, how many would choose to have bowel screening.

In this study the researchers want to find out

  • How many women with womb cancer also have Lynch syndrome
  • How many women with womb cancer would accept testing for Lynch syndrome
  • How many of these would consider yearly bowel screening
  • What their concerns are about having bowel screening

Who can enter

You may be able to join this study if all of the following apply. You

Trial design

This study needs 200 women to join.

The study team may ask you to join at a routine follow up appointment at the outpatient clinic. They may also invite you if you have had surgery and are still recovering on the ward. And you may also join if your surgery for womb cancer was some time ago.  

A member of the team will talk to you about the study. If you agree to join they will ask you about your health, family history and lifestyle. This should take about 15 minutes.

After this you will fill in a short questionnaire. The questionnaire will ask you about why you might decide to have screening, any concerns you may have and what you understand about bowel screening. This will take about 10 minutes.

The researchers will take a blood sample. They will ask your permission for a sample of your cancer that was removed when you had surgery or a biopsy Open a glossary item. They will use these samples to test for the gene faults that causes Lynch syndrome. These tests may take a few months to do.

If you want to know the results of the tests the study team will contact you. Should the results show that you do have Lynch syndrome (or any gene faults) you will be offered advice, support and regular screening for bowel cancer.

Hospital visits

There are no extra hospital visits if you agree to take part in the study.

Side effects

You may have some discomfort or bruising from where the blood samples are taken.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Emma Crosbie

Supported by

Central Manchester University Hospitals NHS Foundation Trust
Medical Research Council (MRC)
NIHR Clinical Research Network: Cancer
University of Manchester

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

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"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

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