“I think it’s really important that people keep signing up to these type of trials to push research forward.”
A study of the link between womb cancer and Lynch syndrome (PETALS)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
Cancer type:
Womb (uterine or endometrial) cancer
Status:
Closed
This study is looking at how many womb cancers are due to Lynch syndrome. It is open to women with womb (endometrial) cancer who are going to the St Mary’s Hospital in Manchester.
More about this trial
Women can have an increased risk of developing womb cancer for a number of reasons including
- Age - this type of cancer is more common in older women
- Being very overweight
- Not having children
Another risk factor is having an 
fault in certain genes () that protects against cancers. One such fault can lead to Lynch syndrome.
People who have (also known as HNPCC) have an increased chance of developing certain cancers including womb cancer and bowel cancer.
When someone has Lynch syndrome they are offered yearly bowel screening to remove any small growths (called bowel ) that may become cancer.
Researchers don’t know how many women with womb cancer also have Lynch syndrome. And if these women knew they had Lynch syndrome, how many would choose to have bowel screening.
In this study the researchers want to find out
- How many women with womb cancer also have Lynch syndrome
- How many women with womb cancer would accept testing for Lynch syndrome
- How many of these would consider yearly bowel screening
- What their concerns are about having bowel screening
Who can enter
You may be able to join this study if all of the following apply. You
- Have womb (endometrial) cancer
- Are going to St Mary’s Hospital in Manchester
- Are at least 18 years old
Trial design
This study needs 200 women to join.
The study team may ask you to join at a routine follow up appointment at the outpatient clinic. They may also invite you if you have had surgery and are still recovering on the ward. And you may also join if your surgery for womb cancer was some time ago.
A member of the team will talk to you about the study. If you agree to join they will ask you about your health, family history and lifestyle. This should take about 15 minutes.
After this you will fill in a short questionnaire. The questionnaire will ask you about why you might decide to have screening, any concerns you may have and what you understand about bowel screening. This will take about 10 minutes.
The researchers will take a blood sample. They will ask your permission for a sample of your cancer that was removed when you had surgery or a . They will use these samples to test for the gene faults that causes Lynch syndrome. These tests may take a few months to do.
If you want to know the results of the tests the study team will contact you. Should the results show that you do have Lynch syndrome (or any gene faults) you will be offered advice, support and regular screening for bowel cancer.
Hospital visits
There are no extra hospital visits if you agree to take part in the study.
Side effects
You may have some discomfort or bruising from where the blood samples are taken.
Recruitment start:
Recruitment end:
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Chief Investigator
Dr Emma Crosbie
Supported by
Central Manchester University Hospitals NHS Foundation Trust
Medical Research Council (MRC)
NIHR Clinical Research Network: Cancer
University of Manchester
Questions about cancer? Contact our information nurses
Freephone 0808 800 4040
Last review date
CRUK internal database number:
13595
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Charlie took part in a trial to try new treatments
Last reviewed:
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