
"I am glad that taking part in a trial might help others on their own cancer journey.”
This study is looking at tissue and blood samples to work out who benefits most from having a PARP inhibitor.
The study is for women who have:
These cancers are treated in the same way. So when we use the term ovarian cancer in this summary, we are referring to all 3.
PARP inhibitors are a type of . They are a treatment for some women with ovarian cancer. Sometimes PARP inhibitors stop working. Doctors call this becoming resistant to treatment. Researchers are running this study to find out why this happens. To do this they are collecting blood and tissue samples. They plan to look at:
The main aims of the trial are to:
The following bullet points are a summary of the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
Please note, there are three groups in this study. Each group has specific entry conditions and we haven’t listed them all.
Who can take part
You may be able to join the study if all of the following apply. You:
Who can’t take part
You cannot join this study if any of these apply. You:
As well as the above there are specific entry conditions for each treatment group. Speak to your doctor or research nurse if you want to find out more about the entry conditions for this trial. |
The study team need 260 people to join the study.
There are 3 groups. You join:
Your doctor will tell you which group you are suitable to join. They check your medical notes for information on your past and present health, and for information about your cancer.
Blood and tissue samples for research
The team ask everyone for a sample of tissue from when they were first diagnosed.
In cohort A you give extra blood samples and you also give a tissue sample if your cancer gets worse.
In cohort B you give a tissue sample when you join the study. The team also collect extra blood samples.
In cohort C, you only give an extra blood sample as part of the study.
Where possible you give the blood samples at the same time as your routine blood tests.
The team plan to use the samples to:
This study is a sample collection study. You shouldn’t have any extra hospital visits if you take part. Where possible the team try to organise to collect the samples when you have a routine hospital visit.
The appointment to collect the tissue sample might take up to 4 hours. The team can tell you more about this.
For those who are having a PARP inhibitor you have regular check ups with your doctor. These happen once a month to begin with. These visits are part of your routine care.
The side effects of giving a tissue sample ( include:
If you have the biopsy using a , there is a small risk of an allergic reaction to the
.
You might have some possible slight bleeding or bruising from the blood tests.
We have more information about the side effects of PARP inhibitors.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Patricia Roxburgh
Artios Pharma Limited
NHS Greater Glasgow and Clyde
Wellbeing of Women
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”