
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
This study is looking at combining mIBG, nivolumab and dinutuximab beta to treat neuroblastoma that has continued to grow during treatment or came back after treatment.
This study is mainly for children and young people. We use the term 'you' in this summary, but if you are a parent, we are referring to your child.
Who can take part
Groups 2 and 3
You have 2 treatments of mIBG, 2 weeks apart.
You start nivolumab 2 weeks after the second dose of mIBG. You have nivolumab every 2 weeks for 30 weeks.
You start dinutuximab beta the day after starting nivolumab. You have it every 6 weeks for 30 weeks.
You have all these 3 drugs as a drip through a central line. This is attached to a pump, this makes it easier to control the amount of the drug that slowly goes into your blood stream.
mIBG
You go to University College London Hospital (UCLH) to have mIBG. You stay in for a few days after.
Because mIBG is a radioactive treatment you must stay in your room while in hospital. You have it over 30 minutes.
Nivolumab
You have nivolumab at Southampton Children’s Hospital. You have it over 1 hour as an in a clinic.
Dinutuximab beta
You have dinutuximab beta at Southampton Children’s Hospital. You have it over 10 days.
You have the first 2 treatments of dinutuximab beta in hospital. The nurses and doctor will monitor you during treatment for any side effects.
After this you might be able to have further treatments at home if your side effects aren’t too bad.
Your central line will then be attached to a small pump that is easy to carry around. You need to go back to the hospital to have the pump removed when the treatment is finished. You doctor will talk to you about this.
Samples
The team will take some extra blood samples and samples when you have your routine tests.
They will use these to find out how well the treatment is working. And to find out what happens to dinutuximab beta in the body.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Juliet Gray
Bristol-Myers Squibb
Eusa Pharma
Experimental Cancer Medicine Centre (ECMC)
Joining Against Cancer in Kids (J-A-C-K)
Solving Kids Cancer (SKC)
University Hospital Southampton NHS Foundation Trust
Freephone 0808 800 4040
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”