
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at whether high intensity focused ultrasound (HIFU) is a useful treatment for symptoms of pelvic cancer such as pain and bleeding. Pelvic cancer is cancer that is in the area between the hip bones.
It is for people whose pelvic cancer has come back. For example, for people who have 1 of the following:
HIFU is the use of high frequency sound waves. These waves deliver a strong beam to a specific part of a cancer. Some cells die when this high intensity ultrasound beam is focused directly onto them.
We know from research that HIFU can treat benign tumours in the pelvis. These are called fibroids. It can also help with pain when cancer has spread to the bone.
In this study, researchers want to see if HIFU can help with symptoms of cancer that include pain and bleeding. In some cases, you might have radiotherapy or chemotherapy to treat these symptoms. But this isn’t always possible or it doesn’t work.
The study is in 2 parts. Part 1 looked at having an MRI scan to see if it was possible to have HIFU. This part of the study is now closed. Part 2 is open and involves having an MRI scan to guide the HIFU to the tumour.
The aim of the study is to see how well MRI guided HIFU helps control symptoms of pelvic cancer that has come back.
Please note – there might not be any direct benefit if you join the study. But it might help other people with troublesome symptoms of cancer in the future.
The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join the study if the following apply.
You:
Who can’t take part
You cannot join this study if any of these apply.
You:
This is a small feasibility study. There are 2 parts to this study. Part 1 is closed. Researchers hope to find 15 people to join part 2.
In part 2, you have HIFU guided by an MRI scan. To begin with you have an MRI scan to check if it is possible to treat your tumour with HIFU.
When the study team have confirmed you are suitable, they will arrange for you to come back to the hospital to have HIFU.
You have a MRI scan to guide the ultrasound to the tumour. Before the treatment you will have a small tube called a cannula put into a vein in your arm. You have drugs to make you sleepy (sedation) through the cannula. And you have a contrast medium to make the MRI scan clearer. You might also have other drugs such as pain relief and possibly an anaesthetic.
The ultrasound then directs sound waves towards the cancer. This generates heat that destroys the cancer cells. When the HIFU treatment is finished you will have another MRI scan.
The treatment takes about 1 to 2 hours. You have another MRI scan immediately after treatment.
It takes up to 4 hours for you to recover afterwards. You might have some pain afterwards.
Quality of life
The researchers will ask you to fill in a diary for 30 days after treatment where you record your symptoms.
You have HIFU at the hospital. 1 week after treatment you have a check up and another MRI scan.
You have a follow up appointment at:
People who have been treated with HIFU so far have had very few side effects
.
The possible minor side effects of HIFU include:
The possible more serious complications include:
Your doctor will keep a close eye on you and treat any of these complications straight away.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Prof Nandita de Souza
Cancer Research UK
Institute of Cancer Research
The Royal Marsden NHS Foundation Trust
National Institute of Health Research (NIHR)
Freephone 0808 800 4040
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.