Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A study of genetic characteristics and suitability for targeted cancer treatment (TARGET)
More about this trial
- about DNA changes in blood and tissue samples of advanced solid tumours
- how cancer cells grow
- how different targeted treatments might work
- why treatments work in some people and not in others
Who can enter
- have an advanced solid tumour. A solid tumour is any type of cancer apart from a cancer of the blood system or lymphatic system such as leukaemia or lymphoma
- have been referred for a phase 1 trial at the Christie hospital in Manchester
- are fit enough to have an experimental cancer drug
- are able to have a biopsy
- are willing for doctors to use an old tissue sample if a biopsy is not possible
- are aged 18 or over
- have HIV, Hepatitis B or Hepatitis C
- are not eligible to join a phase 1 clinical trial
- have a physical or mental health problem that the trial team think will affect your taking part in the trial
- have blood clotting problems that are not controlled with medications
- have any other conditions that prevent blood samples and biopsies being taken
This study is in 2 parts.
The first part of the study was a feasibility study to check the trial was possible. Part 1 has successfully completed.
People who participated in part 1 might still be able to take part in part 2.
The second part of this study will recruit more than 400 patients. This part of the study is running for 3 years.
The aim of this part of the study is to match each patient to a phase 1 trial, based on the alterations in their DNA.
- taking your medical history
- blood tests
- a tissue sample (biopsy)
- a sample of fluid drained from the lungs (pleural effusion)
- a sample of fluid drained from the abdomen (ascitic fluid)
- your risk of other medical conditions not related to your cancer
- increased risk of cancer and other medical conditions for your biological family
How to join a clinical trial
Dr Matthew Krebs
Cancer Research UK Manchester Institute
Experimental Cancer Medicine Centre (ECMC)
Manchester Centre for Genomic Medicine
Manchester Cancer Research Centre (MCRC)
The Christie NHS Foundation trust