
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at using CMD 003 T cells to treat a rare type of non Hodgkin lymphoma called NK/T cell lymphoma.
The Epstein Barr virus (EBV) is found in all people who have NK/T cell lymphoma. This virus is able to hide the infected lymphoma cells from the body’s immune system. This means these cells can avoid being found and destroyed.
T cells are a part of the body’s immune system. Researchers want to create T cells that are able to recognise cells infected with the Epstein Barr virus.
To create the T cells you have a blood sample taken. Your blood is then sent to a laboratory and processed to produce the T cells, called CMD 003 T cells. These are then given back to you.
The team hope that, by destroying the EBV-infected cells, the CMD 003 T cells can help shrink the lymphoma.
The aims of this study are to find how well CMD 003 T cells work for NK/T lymphoma and how safe it is.
The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
There are 2 parts to this study, screening and treatment.
You may be able to join the screening part of this study if you have a rare type of non Hodgkin lymphoma called extranodal NK/T lymphoma and are in one of the following situations.
And all of the following apply:
To join the treatment part of this study all of the following must apply.
You cannot join this study if any of these apply.
Cancer related
Medical conditions
Other
You cannot join the treatment stage of this study if any of the following apply.
This is a phase 2 study. The team need 35 people to treat.
There are 2 parts to this study the screening part and treatment part. You are asked to join each part separately.
Even if you are in the screening part, you might not be able to join the treatment part. Your doctor will talk to you about this and what other treatment is available if this is the case for you.
Screening
You have about 200mls of blood taken. The CMD 003 T cells are made in the laboratory from your blood. This takes about 40 days to do.
During this time your doctor might give you some chemotherapy. They will talk about this with you if needed.
Treatment
You have the CMD 003 T cells as a drip into a vein. This takes about 10 minutes.
You have the 2nd treatment 2 weeks after the first and then at:
You can have up to 5 treatments as long as it is helping and the side effects aren’t too bad.
After each treatment you stay in the clinic for at least 2 hours. So the nurses can monitor you if you have any side effects. You may need to stay longer if the doctor feels it is necessary.
Samples
The researchers will ask for extra blood samples during the study. They use these to see how well the CMD 003 T cells treatment works. And how it affects your .
If you have a skin wound that is caused by the lymphoma the team will ask for a sample of tissue () of this.
They will also ask people for a biopsy of their lymphoma if a suitable area can be found.
The samples are used to find more about how CMD 003 T cells work and how to improve it.
You see the doctor to have some tests before you take part in the treatment part. These include:
You see the doctor several times for a year for the same tests. During the year you have 4 more PET-CT scans.
After this a member of the study team will phone you 4 times in the next 18 months to see how you.
Few side effects have been linked to giving CMD 003 T cells. In some people the T cells have caused inflammation leading to a high temperature (fever), flu like symptoms and swelling where the lymphoma is. Depending on where the lymphoma is this could lead to problems such as breathing difficulties that could be dangerous or life threatening.
This is most likely to happen very soon after having treatment. So you stay in the clinic and are monitored by the staff for at least 2 hours after each treatment. This is to make sure you are okay before sending you home.
Other reactions to having CMD 003 T cells may include:
Your doctor will talk to you about the side effects of CDM 003 T cells before you agree to take part.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor J.A. Radford
Cell Medica Ltd
Experimental Cancer Medicine Centre (ECMC)
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”