Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A study to collect samples and information about family history in children and young people with low grade gliomas (Transcal)
The study worked with the CCLG (Children's Cancer and Leukaemia Group) tissue bank. Together they aimed to provide researchers with valuable information about low grade glioma in children and young people.
More about this trial
A glioma is a type of brain tumour. A glioma can be low grade or high grade. Low grade gliomas generally grow more slowly.
The researchers asked parents and some older children to fill in a questionnaire about their
The aim of this study was to collect different sorts of information and put it together in one place, called a dataset. Samples (
Researchers in the future could then use this dataset to learn
- How genes affect the risk of developing a low grade glioma
- If a person’s
genesaffect how they respond to treatment
Summary of results
The study team successfully set up a dataset to be used for future research.
Any information and samples collected by the study team were made anonymous. This means it is not possible to link any information back to the individual patient.
Family history questionnaire
The study team collected 377 questionnaires from 209 families. Of the 209 families taking part, 168 of these had information collected from both parents.
Of the 209 families
- 34 families had 2 relatives affected by cancer (either first degree or second degree)
- 9 families had 3 relatives affected by cancer
- 5 families had more than 4 relatives affected by cancer
A first degree relative is a parent, brother or sister, son or daughter. A second degree relative is a grandparent, nephew or niece, aunt or uncle, or grandchild.
Researchers already know that those families where a child has low grade glioma have a greater chance of having other cancers in the family.
Tissue and blood samples
The study collected 132 tissue samples and 155 blood samples from the children taking part. These samples are also registered with the CCLG Tumour Bank.
The study was able to collect a questionnaire and at least one sample from 162 of the children.
The dataset is now available for researchers to use in future studies. They can search the dataset to look for patients with a family history of cancer and to look for relatives with a particular type of cancer.
In the future the plan is that the dataset will allow researchers to look further at the samples of tissue and blood collected from the children and young people with low grade glioma.
We have based this summary on information from the research team. As far as we are aware, the information they sent us has not been reviewed independently (
How to join a clinical trial
Professor David Walker
Cancer Research UK
Children's Cancer and Leukaemia Group (CCLG)
NIHR Clinical Research Network: Cancer