There are separate parts to this study. Which part you are in will depend on your cancer type and when you join.
This is a phase 1 study. The study team need about 156 people in total to take part.
The first few people to take part will have a low dose of ceralasertib. If they don’t have any bad side effects the next few will have a higher dose. And so on until the highest safe dose is found. This is a dose escalation study.
After this they want to find the best dose of ceralasertib to give with:
They do this the same way as above. Which drug you have depends on your type of cancer.
Ceralasertib is a tablet. You take it on an empty stomach. You can’t eat or drink anything apart from water for 2 hours before, or an hour after, taking your tablets. Your doctor will tell you how many to take.
You have carboplatin as a drip into a vein every 3 or 4 weeks. You have 6 treatments.
Olaparib is a tablet. Your doctor will tell you when to take them and how many.
You continue having olaparib and ceralasertib for as long as it is helping you and the side effects aren’t too bad.
You have durvalumab as a drip into a vein every 6 weeks. You continue having durvalumab and ceralasertib for as long as it is helping you and the side effects aren’t too bad.
AZD5305 is a tablet. You take it once a day every day. You can’t eat or drink anything apart from water for 2 hours before, or an hour after, taking your tablets. You continue to take ceralasertib and AZD5305 as long as it is helping and the side effects aren't too bad.
Samples
The researchers will ask for samples of tissue (biopsy
).These might be samples you have had taken previously. Or they may ask you to have a biopsy done while you are in the study. Not everyone will need to have additional biopsies. It will depend on which part of the study you join. The researchers will explain more.
You have some additional blood tests as part of this study. These are to measure specific substances in the blood (biomarkers
).
You will be asked if you’re willing to have an extra blood test. This is for genetic research. You do not have to give this sample if you don’t want to. You can still take part in the main study.
The researchers use all these samples to find out more about cancer and how ceralasertib works.